Remodelling by macula densa cells

IF 28.6 1区 医学 Q1 UROLOGY & NEPHROLOGY
Susan J. Allison
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引用次数: 0
黄斑部细胞的重塑
肾小管黄斑(MD)细胞能感知肾小管液体的变化,从而控制肾血流量和肾素释放等功能。新发现确定了MD细胞在肾组织重塑中的更广泛作用。"研究人员说:"已确定的细胞......特征......表明,MD是肾小管中一种比以前认为的要复杂得多的关键感觉和调节细胞类型。为了研究肾脏组织重塑的动力学,Georgina Gyarmati及其同事在报告小鼠体内进行了连续的体内多光子显微镜观察和遗传细胞命运追踪,结果表明,体液和盐的流失--而不是缺血再灌注诱导的肾损伤--可作为MD激活刺激因子,招募间充质和内皮前体细胞。前体细胞被招募后,在最靠近MD的区域分化并诱导血管、间质和肾小球的重塑。
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来源期刊
Nature Reviews Nephrology
Nature Reviews Nephrology 医学-泌尿学与肾脏学
CiteScore
39.00
自引率
1.20%
发文量
127
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.
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