Growth arrest-specific protein 6 as a marker of nephritis in systemic sclerosis and juvenile systemic lupus erythematosus patients.

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2024-08-01 Epub Date: 2024-05-29 DOI:10.1177/09612033241257321
Alshymaa A Ahmed, Dina Said, May M Sami
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Abstract

Background: Renal impairments commonly occur as a complication of autoimmune connective tissue diseases (CTDs). Therefore, early nephritis prediction is vital for patient outcomes. Growth Arrest-Specific Protein 6 (GAS6) was found to be upregulated in many types of inflammatory renal disease, including diabetic nephropathy.Aim: To evaluate GAS6 as a predictor of renal impairment in adults with systemic sclerosis (SSc) and children with systemic lupus Erythematosus (SLE).Methods: The study included 60 patients with SSc and 40 children with SLE. The serum level of GAS6 was measured using the ELISA technique. In adults with SSc, total proteins in 24-h urine concentration of >300 mg/24 h indicated renal inflammation, while in children with SLE, nephritis was diagnosed by abnormal renal pathology.Results: In SSc patients, GAS6 significantly increased in patients with proteinuria. GAS6 is an independent predictor of nephritis with an odds ratio (OR) of 1.06 and a 95% confidence interval (CI) of 1.0-1.1. at cutoff 12.2 ng/mL GAS6 predicted proteinuria with sensitivity 86.7% (95% CI: 59.5% to 98.3%), specificity 57.8% (95% CI: 42.1% to 72.3%), positive predictive value 40.6% (95% CI: 31.5% to 50.4%), negative predictive value 92.9% (95% CI: 77.7% to 97.73%), and accuracy 65.0% (95% CI: 51.6% to 76.9%). In SLE patients, Serum GAS6 did not differ significantly between children with and without lupus nephritis.Conclusion: GAS6 is an independent predictor of nephritis in patients with SSc. However, there is no association between GAS6 and nephritis in juvenile patients with SLE.

生长停滞特异性蛋白 6 是系统性硬化症和幼年系统性红斑狼疮患者肾炎的标志物。
背景:肾功能损害通常是自身免疫性结缔组织病(CTD)的并发症之一。因此,早期肾炎预测对患者的预后至关重要。目的:评估 GAS6 作为系统性硬化症(SSc)成人患者和系统性红斑狼疮(SLE)儿童患者肾功能损害预测因子的作用:研究对象包括60名系统性硬化症患者和40名系统性红斑狼疮患儿。采用 ELISA 技术测定血清中 GAS6 的水平。在成人 SSc 患者中,24 小时尿液中总蛋白浓度大于 300 毫克/24 小时表示肾脏有炎症,而在儿童 SLE 患者中,肾脏病理异常可诊断为肾炎:结果:在 SSc 患者中,GAS6 在蛋白尿患者中明显升高。GAS6是肾炎的独立预测因子,其几率比(OR)为1.06,95%置信区间(CI)为1.0-1.1。截止值为12.2 ng/mL时,GAS6预测蛋白尿的灵敏度为86.7%(95% CI:59.5%至98.3%),特异性为57.3%。3%),特异性 57.8%(95% CI:42.1% 至 72.3%),阳性预测值 40.6%(95% CI:31.5% 至 50.4%),阴性预测值 92.9%(95% CI:77.7% 至 97.73%),准确性 65.0%(95% CI:51.6% 至 76.9%)。在系统性红斑狼疮患者中,血清 GAS6 在狼疮性肾炎患儿和非狼疮性肾炎患儿之间没有显著差异:结论:GAS6是预测系统性红斑狼疮患者肾炎的独立指标。结论:GAS6 是预测系统性红斑狼疮患者肾炎的独立指标,但在系统性红斑狼疮青少年患者中,GAS6 与肾炎之间没有关联。
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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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