Plasma triglyceride is associated with the recurrence of atrial fibrillation after radiofrequency catheter ablation: A retrospective study

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-05-30 DOI:10.1002/clc.24276

Qingqing Gu MD, Ye Deng MD, Jun Wei MD, Qianwen Chen MD, Dabei Cai MD, Tingting Xiao MD, Li Deng MD, Yu Wang MD, Qingjie Wang MD, PhD, Ling Sun MD, Yuan Ji MD

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Abstract

Background

The purpose of this study was to explore the association between triglycerides (TGs) and the risk of atrial fibrillation (AF) recurrence.

Methods and Results

Included were adult patients with AF who underwent radiofrequency catheter ablation in the Affiliated Changzhou Second People's Hospital of Nanjing Medical University. The enrolled patients were divided into the AF recurrence group and the sinus rhythm (SR) maintenance group. The univariate Cox regression analysis and Kaplan–Meier survival curve were performed estimate the association between TG and the risk of AF recurrence. Of the 402 patients, 79 (19.7%) experienced recurrence of AF after ablation. The TG level was significantly higher in the AF recurrence group than in the SR-maintaining group. Patients were grouped by quartile of TG levels, with Quartile 1 and Quartile 2 defined as the low concentration group, Quartile 3 as the moderate concentration group, and Quartile 4 as the high concentration group. Multivariate Cox regression analysis showed that the moderate concentration group (p = .02, hazard ratio [HR]: 2.331, 95% confidence interval [CI]: 1.141–4.762) and high concentration group (p = .007, HR: 2.873, 95% CI: 1.332–6.199) were associated with an increased risk of AF recurrence compared with the low concentration group. The median follow-up was 1.17 years, it is indicated that a higher risk of recurrent AF was observed in the moderate concentration and high concentration group (log-rank: χ² = 7.540, p = .023).

Conclusion

Our data suggest that an elevated TG level measured before catheter ablation is associated with an increased risk of AF recurrence.

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血浆甘油三酯与射频导管消融术后心房颤动复发有关：一项回顾性研究。

研究背景本研究旨在探讨甘油三酯（TGs）与心房颤动（AF）复发风险之间的关系：研究对象为在南京医科大学附属常州第二人民医院接受射频导管消融术的成年房颤患者。入组患者分为房颤复发组和窦性心律（SR）维持组。采用单变量 Cox 回归分析和 Kaplan-Meier 生存曲线估算 TG 与房颤复发风险之间的关系。在 402 名患者中，79 人（19.7%）在消融术后出现房颤复发。房颤复发组患者的 TG 水平明显高于维持 SR 组患者。按照 TG 水平的四分位数对患者进行分组，其中四分位数 1 和四分位数 2 被定义为低浓度组，四分位数 3 为中浓度组，四分位数 4 为高浓度组。多变量 Cox 回归分析表明，中等浓度组（p = .02，危险比 [HR]：2.331，95% 置信区间 [CI]：1.141-4.762）和高浓度组（p = ：与低浓度组相比，中浓度组（p = .02，危险比 [HR]：2.331，95% 置信区间 [CI]：1.141-4.762）和高浓度组（p = .007，HR：2.873，95% 置信区间 [CI]：1.332-6.199）与房颤复发风险增加相关。中位随访时间为 1.17 年，结果显示中度浓度组和高浓度组的房颤复发风险更高（log-rank：χ2 = 7.540，P = .023）：我们的数据表明，导管消融术前测量的 TG 水平升高与房颤复发风险增加有关。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464