The impact of low-dose methotrexate on erectile dysfunction, sex hormone profile and spermiogram in male patients with psoriasis: a prospective study.

IF 1.6 4区医学 Q3 OPHTHALMOLOGY

Cutaneous and Ocular Toxicology Pub Date : 2024-09-01 Epub Date: 2024-06-03 DOI:10.1080/15569527.2024.2360736

Hatice Atas, Tuğcan Yüksek, Ahmet Nihat Karakoyunlu, Selda Pelin Kartal, Gamze Taş Aygar

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引用次数: 0

Abstract

Purpose: Psoriasis, affecting approximately 2% of the world's population, often necessitates systemic treatments, with methotrexate (MTX) as a cornerstone therapy. Despite documented systemic side effects of MTX, concerns about its impact on male reproductive health persist. We aim to investigate low-dose MTX effect on hormonal, cellular and functional ability of male reproductive system.

Materials and methods: Our prospective study on 40 male psoriasis patients receiving low-dose MTX (<15mg/week) comprehensively investigates its effects on erectile function, sex hormones, and spermiogram parameters.

Results: After six months of MTX treatment, a significant decline in erectile function (p < 0.001) decreased total testosterone levels (p = 0.03) were observed. No significant reduction in sperm count was noted after six months of MTX treatment.

Conclusions: Our study highlights a significant decline in erectile function following low-dose MTX therapy, warranting further investigation into this potential side effect. While reassuring for sperm quantity and quality, the findings emphasise the necessity for larger cohorts and longer follow-up times to validate results and comprehend the complex interactions between MTX and male sexual health.

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小剂量甲氨蝶呤对男性银屑病患者勃起功能障碍、性激素谱和精子图的影响：一项前瞻性研究。

目的银屑病影响着全球约 2% 的人口，通常需要进行系统治疗，其中甲氨蝶呤 (MTX) 是一种基础疗法。尽管有文献记载 MTX 有全身副作用，但人们仍然担心它对男性生殖健康的影响。我们旨在研究低剂量 MTX 对男性生殖系统激素、细胞和功能能力的影响：我们对接受低剂量 MTX 治疗的 40 名男性银屑病患者进行了前瞻性研究：结果：MTX 治疗 6 个月后，勃起功能显著下降（p 结论：我们的研究强调了勃起功能的显著下降：我们的研究强调了低剂量 MTX 治疗后勃起功能的显著下降，因此有必要对这一潜在的副作用进行进一步调查。虽然这些研究结果对精子的数量和质量起到了保证作用，但同时也强调有必要进行更大规模的队列研究和更长时间的随访，以验证研究结果并理解MTX与男性性健康之间复杂的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cutaneous and Ocular Toxicology 医学-毒理学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

1 months

期刊介绍： Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.