Associations between whole grains intake and new-onset hypertension: a prospective cohort study.

IF 4.1 2区 医学 Q2 NUTRITION & DIETETICS
European Journal of Nutrition Pub Date : 2024-10-01 Epub Date: 2024-05-30 DOI:10.1007/s00394-024-03434-7
Zi-Hao Xu, Xu-Lian Tang, Cheng-Shen Qiu, Hong-Min Li, Dan-Qing Liao, Li-Ying Du, Shu-Min Lai, Hong-Xuan Huang, Zhi-Yuan Xiong, Xiao-Ning Li, Li-Na Zhao, Zhi-Hao Li
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引用次数: 0

Abstract

Importance: Epidemiological evidences regarding the association between whole grain intake and the risk of new-onset hypertension are still controversial.

Objective: We aimed to investigate the relationship between whole grain intake and new-onset hypertension and examine possible effect modifiers in the general population.

Methods: A total of 10,973 participants without hypertension from the China Health and Nutrition Survey were enrolled, with follow-up beginning in 1997 and ending in 2015. Whole grain intake was assessed by 3 consecutive 24-h dietary recalls combined with a household food inventory. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression model after adjusting for potential risk factors.

Results: During a median follow-up of 7.0 years, 3,733 participants developed new-onset hypertension. The adjusted HRs (95% CIs) were as follows: for quartile 2 (HR: 0.52; 95% CI: 0.47-0.57), quartile 3 (HR: 0.46; 95% CI: 0.42-0.51), and quartile 4 (HR: 0.35; 95% CI: 0.31-0.38), compared with quartile 1. Different types of whole grain types, including wheat (adjusted HR, 0.35; 95% CI, 0.32-0.39), maize (adjusted HR, 0.50; 95% CI, 0.42-0.59), and millet (adjusted HR, 0.38; 95% CI, 0.30-0.48), showed significant associations with a reduced risk of hypertension. The association between whole grain intake and new-onset hypertension was stronger in individuals with older age (P for interaction < 0.001) and higher BMI (P for interaction < 0.001).

Conclusion: Higher consumption of whole grains was significantly associated with a lower risk of new-onset hypertension. This study provides further evidence supporting the importance of increasing whole grain intake for hypertension prevention among Chinese adults.

Abstract Image

全谷物摄入量与新发高血压之间的关系:一项前瞻性队列研究。
重要性:有关全谷物摄入量与新发高血压风险之间关系的流行病学证据仍存在争议:我们旨在调查全谷物摄入量与新发高血压之间的关系,并研究普通人群中可能存在的影响因素:方法:我们从中国健康与营养调查中选取了10973名未患高血压的人群作为研究对象,随访始于1997年,结束于2015年。全谷物摄入量通过连续 3 次 24 小时膳食回顾和家庭食物清单进行评估。在调整潜在风险因素后,采用 Cox 比例危险回归模型估算了多变量危险比(HRs)和 95% 置信区间(CIs):在中位 7.0 年的随访期间,3,733 名参与者患上了新发高血压。与四分位数 1 相比,调整后的 HRs(95% CIs)如下:四分位数 2(HR:0.52;95% CI:0.47-0.57)、四分位数 3(HR:0.46;95% CI:0.42-0.51)和四分位数 4(HR:0.35;95% CI:0.31-0.38)。不同类型的全谷物,包括小麦(调整后的 HR 值为 0.35;95% CI 值为 0.32-0.39)、玉米(调整后的 HR 值为 0.50;95% CI 值为 0.42-0.59)和小米(调整后的 HR 值为 0.38;95% CI 值为 0.30-0.48),都与高血压风险的降低有显著关联。年龄越大,全谷物摄入量与新发高血压之间的关系越密切(P 为交互作用结论):全谷物摄入量越高,新发高血压的风险越低。这项研究进一步证明了增加全谷物摄入对中国成年人预防高血压的重要性。
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来源期刊
CiteScore
10.20
自引率
2.00%
发文量
295
审稿时长
6 months
期刊介绍: The European Journal of Nutrition publishes original papers, reviews, and short communications in the nutritional sciences. The manuscripts submitted to the European Journal of Nutrition should have their major focus on the impact of nutrients and non-nutrients on immunology and inflammation, gene expression, metabolism, chronic diseases, or carcinogenesis, or a major focus on epidemiology, including intervention studies with healthy subjects and with patients, biofunctionality of food and food components, or the impact of diet on the environment.
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