Obesity and gestation in Criollo mares: endocrine and metabolic profiles

IF 1.9 2区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Mateo Pardié , Irene Kalpokas , Francesca Freccero , Carolina Castagnetti , Ana Meikle
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Abstract

The aim of this study was to determine the effect of body condition score (BCS) on metabolic and endocrine parameters in pregnant Criollo mares (n=41), which were categorized according to their BCS as obese (7 to 9 BCS, n=26) or normal (5 to 7, n=15). Blood samples were taken during gestation in 3 periods: between 3.5 and 5 months (I), 8 and 9 months (II) and in the last month of gestation (III). The data was analyzed in the statistical model by mixed procedures, including BCS, gestational period and their interaction as fixed effects. BCS was only different in period I, as normal mares increased their BCS in the later periods. Leptin concentrations were greater in obese mares when compared to non-obese mares during all sampling periods (P<0.01), while glucose concentrations were also greater in the former group (P<0.01) but only during the first sampling period. Insulin concentrations and homeostatic model assessment for insulin resistance (HOMA-IR) index were greater also in obese mares in periods I and III (P<0.05). Adiponectin concentrations in period I were lower in obese mares (P<0.05). Cholesterol concentrations increased during gestation, and obese mares tended to have greater concentrations than nonobese mares (P<0.1). Triglyceride concentrations were not affected by group or gestational period. This study revealed adaptations in carbohydrate and lipid metabolism during gestation in mares. Several parameters are dependent on the degree of body fat reserves, which are reflected in the concentrations of biomarkers such as leptin and adiponectin. Insulin concentration in obese mares was higher than non-obese mares at the end of gestation, a similar profile was observed for HOMA-IR although cutoff values are yet still to be validated.

Criollo 母马的肥胖和妊娠:内分泌和代谢特征。
本研究旨在确定体况评分(BCS)对妊娠克里奥罗母马(41 头)代谢和内分泌参数的影响,根据体况评分将妊娠克里奥罗母马分为肥胖(体况评分为 7-9 分,26 头)和正常(5-7 分,15 头)两类。血液样本在妊娠期间分三个时期采集:3.5 至 5 个月(I)、8 至 9 个月(II)和妊娠最后一个月(III)。数据采用混合程序的统计模型进行分析,将 BCS、妊娠期及其交互作用作为固定效应。BCS仅在妊娠期I存在差异,正常母马的BCS在妊娠期后期有所增加。与非肥胖母马相比,肥胖母马在所有采样期的瘦素浓度都更高(P
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来源期刊
Domestic animal endocrinology
Domestic animal endocrinology 农林科学-奶制品与动物科学
CiteScore
5.50
自引率
4.80%
发文量
58
审稿时长
31 days
期刊介绍: Domestic Animal Endocrinology publishes scientific papers dealing with the study of the endocrine physiology of domestic animal species. Those manuscripts utilizing other species as models for clinical or production problems associated with domestic animals are also welcome. Topics covered include: Classical and reproductive endocrinology- Clinical and applied endocrinology- Regulation of hormone secretion- Hormone action- Molecular biology- Cytokines- Growth factors
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