SERS biosensors for liquid biopsy towards cancer diagnosis by detection of various circulating biomarkers: current progress and perspectives

IF 13.4 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Nano Convergence Pub Date : 2024-05-29 DOI:10.1186/s40580-024-00428-3

Nana Lyu, Amin Hassanzadeh-Barforoushi, Laura M. Rey Gomez, Wei Zhang, Yuling Wang

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引用次数: 0

Abstract

Liquid biopsy has emerged as a promising non-invasive strategy for cancer diagnosis, enabling the detection of various circulating biomarkers, including circulating tumor cells (CTCs), circulating tumor nucleic acids (ctNAs), circulating tumor-derived small extracellular vesicles (sEVs), and circulating proteins. Surface-enhanced Raman scattering (SERS) biosensors have revolutionized liquid biopsy by offering sensitive and specific detection methodologies for these biomarkers. This review comprehensively examines the application of SERS-based biosensors for identification and analysis of various circulating biomarkers including CTCs, ctNAs, sEVs and proteins in liquid biopsy for cancer diagnosis. The discussion encompasses a diverse range of SERS biosensor platforms, including label-free SERS assay, magnetic bead-based SERS assay, microfluidic device-based SERS system, and paper-based SERS assay, each demonstrating unique capabilities in enhancing the sensitivity and specificity for detection of liquid biopsy cancer biomarkers. This review critically assesses the strengths, limitations, and future directions of SERS biosensors in liquid biopsy for cancer diagnosis.

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用于液体活检的 SERS 生物传感器，通过检测各种循环生物标记物诊断癌症：当前进展与前景。

液体活检已成为一种前景广阔的非侵入性癌症诊断策略，可检测各种循环生物标记物，包括循环肿瘤细胞（CTC）、循环肿瘤核酸（ctNA）、循环肿瘤衍生小细胞外囊泡（sEV）和循环蛋白质。表面增强拉曼散射（SERS）生物传感器为这些生物标记物提供了灵敏而特异的检测方法，从而彻底改变了液体活检。这篇综述全面探讨了基于 SERS 的生物传感器在用于癌症诊断的液体活检中用于识别和分析各种循环生物标记物（包括 CTC、ctNA、sEV 和蛋白质）的应用。讨论涵盖了多种 SERS 生物传感器平台，包括无标记 SERS 检测、基于磁珠的 SERS 检测、基于微流控装置的 SERS 系统和基于纸张的 SERS 检测，每种平台都在提高检测液体活检癌症生物标记物的灵敏度和特异性方面展示了独特的能力。这篇综述认真评估了 SERS 生物传感器在液体活检癌症诊断中的优势、局限性和未来发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano Convergence Engineering-General Engineering

CiteScore

15.90

自引率

2.60%

发文量

审稿时长

13 weeks

期刊介绍： Nano Convergence is an internationally recognized, peer-reviewed, and interdisciplinary journal designed to foster effective communication among scientists spanning diverse research areas closely aligned with nanoscience and nanotechnology. Dedicated to encouraging the convergence of technologies across the nano- to microscopic scale, the journal aims to unveil novel scientific domains and cultivate fresh research prospects. Operating on a single-blind peer-review system, Nano Convergence ensures transparency in the review process, with reviewers cognizant of authors' names and affiliations while maintaining anonymity in the feedback provided to authors.