Multidimensional assessment of social cognition using non-immersive virtual reality in dementia with Lewy bodies and Alzheimer's disease: an exploratory study.

IF 1.8 4区 心理学 Q3 CLINICAL NEUROLOGY
Eva-Flore Msika, Marc Verny, Bénédicte Dieudonné, Nathalie Ehrlé, Alexandre Gaston-Bellegarde, Eric Orriols, Pascale Piolino, Pauline Narme
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引用次数: 0

Abstract

Introduction: Few studies have focused on social cognition in dementia with Lewy bodies (DLB), even though some brain structures being well known as underlying social cognitive processes are directly impacted in this disease. Furthermore, social cognition processes have been mostly studied independently using evaluations with poor ecological validity. We aimed at studying the ability of a new naturalistic and multidimensional social cognition task to reveal impairments in DLB patients. We chose to compare the profile of these patients with that of Alzheimer's disease (AD) patients, for which social cognition is better preserved.

Method: Fifteen patients (DLB: n = 7; AD: n = 8) and 28 healthy controls underwent the REALSoCog task. They encountered several social situations (e.g. control versus transgressions) in a non-immersive virtual city environment allowing the assessment of moral cognition, cognitive and affective theory of mind (ToM), emotional empathy and behavioral intentions.

Results: The main results showed (i) a lower ability to detect transgressions in DLB patients, particularly conventional ones, whereas moral cognition seemed better preserved in AD patients; (ii) a cognitive ToM impairment in both DLB and AD patients, while affective ToM is impaired only in DLB patients; (iii) a decreased emotional empathy specifically observed in DLB patients; (iv) more inappropriate behavioral intentions, mainly in DLB patients, but also in some AD patients.

Conclusions: This study suggests the feasibility and potential interest of the REALSoCog task in revealing social cognition deficits, particularly for DLB patients by showing different social patterns as compared to AD patients. These results offer interesting clinical perspectives to develop more naturalistic tasks in such populations and for clinical differential diagnosis. Limitations and future perspectives are discussed.

利用非沉浸式虚拟现实技术对路易体痴呆症和阿尔茨海默氏症患者的社会认知进行多维度评估:一项探索性研究。
引言尽管众所周知,路易体痴呆症(DLB)的某些大脑结构会直接影响患者的社会认知过程,但很少有研究关注这种疾病的社会认知过程。此外,对社会认知过程的研究大多采用生态效度较差的独立评估。我们的目的是研究一种新的自然多维社会认知任务揭示 DLB 患者损伤的能力。我们选择将这些患者的情况与阿尔茨海默病(AD)患者的情况进行比较,后者的社会认知能力保存得更好:15 名患者(DLB:n = 7;AD:n = 8)和 28 名健康对照者接受了 REALSoCog 任务。他们在非沉浸式虚拟城市环境中遇到了几种社会情境(如控制与过失),从而对道德认知、认知和情感心智理论(ToM)、情感共鸣和行为意图进行了评估:主要结果显示:(i) DLB 患者发现越轨行为的能力较低,尤其是传统越轨行为,而注意力缺失症患者的道德认知似乎保存得更好;(ii) DLB 和注意力缺失症患者的认知心智理论(ToM)均受损,而情感心智理论(ToM)仅在 DLB 患者中受损;(iii) DLB 患者的情感共鸣明显降低;(iv) 主要在 DLB 患者中,但在一些注意力缺失症患者中,不当行为意向较多:本研究表明,REALSoCog 任务在揭示社会认知缺陷方面具有可行性和潜在的兴趣,特别是通过显示与注意力缺失症患者不同的社会模式,揭示了 DLB 患者的社会认知缺陷。这些结果为在此类人群中开发更多自然任务和临床鉴别诊断提供了有趣的临床视角。本文还讨论了研究的局限性和未来展望。
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来源期刊
CiteScore
3.20
自引率
4.50%
发文量
52
审稿时长
6-12 weeks
期刊介绍: Journal of Clinical and Experimental Neuropsychology ( JCEN) publishes research on the neuropsychological consequences of brain disease, disorders, and dysfunction, and aims to promote the integration of theories, methods, and research findings in clinical and experimental neuropsychology. The primary emphasis of JCEN is to publish original empirical research pertaining to brain-behavior relationships and neuropsychological manifestations of brain disease. Theoretical and methodological papers, critical reviews of content areas, and theoretically-relevant case studies are also welcome.
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