Oral vaccination of young broilers with a live Salmonella Typhimurium vaccine reduces caecal and internal organ colonization following a Salmonella Infantis challenge in a seeder-bird model.

IF 2.5 2区农林科学 Q1 VETERINARY SCIENCES

Avian Pathology Pub Date : 2024-12-01 Epub Date: 2024-06-26 DOI:10.1080/03079457.2024.2362223

Venessa Eeckhaut, Nathalie Van Rysselberghe, Serge Verbanck, Richard Ducatelle, Filip Van Immerseel

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引用次数: 0

Abstract

Poultry products are an important source of foodborne Salmonella infections in humans. Amongst these, the prevalence of S. Infantis is rising. In this study, the protection efficacy of an authorized live-attenuated S. Typhimurium vaccine against S. Infantis, was examined using a seeder-bird model in broilers. Vaccinated birds displayed a significantly lower colonization of S. Infantis bacteria in the caeca compared to the non-vaccinated counterparts (P = 0.017), with no significant differences observed in the spleen among the groups, three days post-infection. Thirty-two days post-infection, the disparity in average S. Infantis concentration between all-vaccinated and non-vaccinated birds was significant in both caeca (P = 0.0003) and spleen (P = 0.0002). Interestingly, a third group, consisting of seeder birds that were not vaccinated but housed with vaccinated penmates, exhibited significantly lower S. Infantis levels in both caeca (P = 0.0014) and spleen (P < 0.0001) compared to the non-vaccinated group. These findings underscore the potential of a live-attenuated S. Typhimurium vaccine administered to 2-day-old chicks in conferring protection against S. Infantis in broilers up to slaughter age.

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在种禽模型中，幼雏肉鸡口服鼠伤寒沙门氏菌活疫苗可减少因凡蒂斯沙门氏菌挑战后的盲肠和内脏器官定植。

禽类产品是人类食源性沙门氏菌感染的重要来源。其中，S. Infantis 的发病率正在上升。在这项研究中，我们使用肉鸡播种机模型检测了已获授权的鼠伤寒减毒活疫苗对因凡蒂斯沙门氏菌的保护效果。与未接种疫苗的肉鸡相比，接种疫苗的肉鸡在盲肠中的 S. Infantis 细菌定植率明显较低（p = 0.017），而在感染后三天，各组之间在脾脏中未观察到明显差异。感染后 32 天，所有接种疫苗和未接种疫苗的鸟类在盲肠（p = 0.0003）和脾脏（p = 0.0002）中的平均 S. Infantis 浓度差异显著。有趣的是，由未接种疫苗但与接种疫苗的栏友同舍的种鸡组成的第三组，其盲肠（p = 0.0014）和脾脏（p < 0.0001）中的 S. Infantis 含量均显著低于未接种疫苗组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Avian Pathology 农林科学-兽医学

CiteScore

4.50

自引率

10.70%

发文量

审稿时长

1 months

期刊介绍： Avian Pathology is the official journal of the World Veterinary Poultry Association and, since its first publication in 1972, has been a leading international journal for poultry disease scientists. It publishes material relevant to the entire field of infectious and non-infectious diseases of poultry and other birds. Accepted manuscripts will contribute novel data of interest to an international readership and will add significantly to knowledge and understanding of diseases, old or new. Subject areas include pathology, diagnosis, detection and characterisation of pathogens, infections of possible zoonotic importance, epidemiology, innate and immune responses, vaccines, gene sequences, genetics in relation to disease and physiological and biochemical changes in response to disease. First and subsequent reports of well-recognized diseases within a country are not acceptable unless they also include substantial new information about the disease or pathogen. Manuscripts on wild or pet birds should describe disease or pathogens in a significant number of birds, recognizing/suggesting serious potential impact on that species or that the disease or pathogen is of demonstrable relevance to poultry. Manuscripts on food-borne microorganisms acquired during or after processing, and those that catalogue the occurrence or properties of microorganisms, are unlikely to be considered for publication in the absence of data linking them to avian disease.