Synergistic Enhancement of Mechanical Strength and Antibacterial Activity in 3D Core–Shell Bone Scaffolds Incorporating Phosphate-Modified Pomegranate Peel Powder Within Polylactic Acid/Poly (Glycerol-Succinic Acid) Composite

IF 4.7 3区 工程技术 Q2 ENGINEERING, ENVIRONMENTAL
Mohammadreza Shojaei, Davood Bizari, Shahrokh Shojaei, Pedram Tehrani, Mohsen Korani, Lokman Uzun, Wei-Hsin Chen, Vahabodin Goodarzi
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Abstract

Despite the imposing regenerative abilities of bone tissue, accomplishing rapid and successful bone regeneration remains challenging due to the complex back-and-forth of factors influencing the healing process. In bone tissue engineering, the mechanical strength and biocompatibility of 3D polymeric scaffolds, which the former is more challenging for bone tissue, are yet to be an unsolved problem. Herein, 3D cylindrical core–shell scaffolds were fabricated by dual-leaching technique using poly (Glycerol-Succinic Acid) (PGSU) as the sell, in combination with phosphate-modified pomegranate peels powder, and poly lactic acid (PLA). The main objective of developing such scaffolds is not only to improve compressive strength but also to enhance cell viability and antibacterial activity. Overall results confirmed that the developed core–shell scaffold, containing phosphate-modified pomegranate peel powder, on one hand, had an appropriate compressive strength due to the presence of PLA in its core; on the other hand, showed acceptable antibacterial activity for using pomegranate powder. Also, it demonstrated that the surface modification was successfully done. By incorporating phosphate-modified pomegranate peel powder into the core–shell scaffold, compressive strength of almost 6000 Pa was achieved, with a porosity of 90% alongside cell viability of almost 100%, as indicated by the MTT assay. The main reason for the appropriate biological response of the developed scaffold relevant to the biomolecule compounds presented in pomegranate powder, including tannins, phytochemicals, flavonoids, and antioxidants, as well as the presence of phosphate ions. Therefore, as the final perspective, the synergistic effects resulting from the combination of the scaffold's structural properties and the antibacterial properties of phosphate-modified pomegranate powder contribute to its overall effectiveness.

Abstract Image

在聚乳酸/聚(甘油-琥珀酸)复合材料中加入磷酸盐改性石榴皮粉的三维核壳骨支架中协同增强机械强度和抗菌活性
尽管骨组织具有强大的再生能力,但由于影响愈合过程的因素错综复杂,要实现快速、成功的骨再生仍具有挑战性。在骨组织工程中,三维聚合物支架的机械强度和生物相容性是一个尚未解决的问题,而前者对于骨组织来说更具挑战性。本文以聚甘油琥珀酸(PGSU)为卖体,结合磷酸盐改性石榴皮粉和聚乳酸(PLA),通过双浸出技术制备了三维圆柱形核壳支架。开发这种支架的主要目的不仅是提高抗压强度,还能增强细胞活力和抗菌活性。总体结果证实,所开发的含有磷酸盐改性石榴皮粉末的核壳支架,一方面由于其核中含有聚乳酸而具有适当的抗压强度,另一方面由于使用了石榴粉末而显示出可接受的抗菌活性。此外,它还表明表面改性已成功完成。在核壳支架中加入磷酸盐改性的石榴皮粉末后,抗压强度达到近 6000 Pa,孔隙率达到 90%,细胞存活率几乎达到 100%(MTT 法)。石榴粉中含有的生物大分子化合物(包括单宁酸、植物化学物质、类黄酮和抗氧化剂)以及磷酸盐离子是所开发的支架产生适当生物反应的主要原因。因此,从最终的角度来看,支架的结构特性与磷酸盐改性石榴粉的抗菌特性相结合所产生的协同效应有助于提高石榴粉的整体功效。
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来源期刊
Journal of Polymers and the Environment
Journal of Polymers and the Environment 工程技术-高分子科学
CiteScore
9.50
自引率
7.50%
发文量
297
审稿时长
9 months
期刊介绍: The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.
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