Polyoxygenated cyclohexenes from the fruits of Uvaria cordata (Dunal) Alston

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-05-28 DOI:10.1016/j.phytol.2024.05.011

Virayu Suthiphasilp , Panom Winyayong , Phunrawie Promnart

引用次数: 0

Abstract

The phytochemical investigation of Uvaria cordata (Dunal) Alston resulted in the isolation and identification of eight cyclohexene derivatives (1–8) and a tetrahydroxanthene-1,3(2H)-dione (9). Among them, compounds 1 and 2 were previously undescribed compounds, and their structures were characterized by intensive spectroscopic data and HRESITOFMS. Compound 7 ((+)-(5 S)-grandiuvarone) exhibited NO production inhibitory with an IC₅₀ value of 34.1 μM, which was better than the standard compound, indomethacin (IC₅₀ = 51.3 μM).

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来自 Uvaria cordata (Dunal) Alston 果实的聚氧环己烯

通过对 Uvaria cordata (Dunal) Alston 进行植物化学研究，分离并鉴定了 8 种环己烯衍生物（1-8）和 1 种四氢蒽-1,3(2H)-二酮（9）。其中，化合物 1 和 2 是以前未曾描述过的化合物，它们的结构是通过密集的光谱数据和 HRESITOFMS 确定的。化合物 7（(+)-(5 S)-格兰迪瓦隆）具有抑制 NO 生成的作用，其 IC50 值为 34.1 μM，优于标准化合物吲哚美辛（IC50 = 51.3 μM）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.