Telomere Length is Associated with the Prevalence, Persistence, and Incidence of Sarcopenia

IF 4.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Aaron Salinas-Rodriguez , Betty Manrique-Espinoza , Ana Rivera-Almaraz , José Manuel Sánchez-López , Haydeé Rosas-Vargas
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引用次数: 0

Abstract

Background

Telomere length (TL) shortening has been identified as a marker of aging and associated with adverse health outcomes, but evidence of its association with sarcopenia is inconclusive.

Aims

Estimate the cross-sectional and prospective associations between TL and sarcopenia.

Methods

We used data from Waves 3 and 4 (2017, 2021) of the Study on Global Aging and Adult Health in Mexico (SAGE-Mexico). The cross-sectional sample consisted of 1,738 adults aged 50 and older, and the longitudinal sample consisted of 1,437. Relative TL was determined by real-time quantitative polymerase chain reaction (qPCR) on DNA extracted from saliva samples and quantified as the telomere/single-copy gene (T/S) ratio. Sarcopenia was defined according to the European Working Group on Sarcopenia in Older People (EWGSOP2).

Results

The mean salivary TL was 1.50 T/S units (95% CI: 1.49–1.52). The baseline prevalence of sarcopenia was 13.3% (95% CI: 9.8–16.8%). The incidence and persistence of sarcopenia were 6.8% (95% CI: 5.0–9.5%) and 7.0% (95% CI: 5.1–9.6%), respectively. The results showed that a one standard deviation decrease in TL was cross-sectionally associated with higher odds of sarcopenia (OR = 1.31; 95% CI: 1.03–1.67) and prospectively with a higher incidence (RRR = 1.55; 95% CI: 1.06–2.25) and persistence (RRR = 1.50; 95% CI: 1.01–2.24) of sarcopenia.

Conclusions

Older adults with shorter TL had higher rates of incident and persistent sarcopenia. Implementation of interventions to delay the decline of TL in older adults is warranted. Further translational studies are needed to elucidate the effects of exercise or diet on DNA repair in the telomeric region and their associations with sarcopenia.

端粒长度与 "肌肉疏松症 "的患病率、持续时间和发病率有关。
背景:端粒长度(TL)缩短已被确定为衰老的标志物,并与不良健康结果相关,但其与肌肉疏松症的关联证据尚不确定。目的:估计端粒长度与肌肉疏松症之间的横断面和前瞻性关联:我们使用了墨西哥全球老龄化与成人健康研究(SAGE-Mexico)第 3 波和第 4 波(2017 年、2021 年)的数据。横向样本包括 1738 名 50 岁及以上的成年人,纵向样本包括 1437 名成年人。通过对唾液样本中提取的 DNA 进行实时定量聚合酶链反应(qPCR)测定相对端粒长度,并以端粒/单拷贝基因(T/S)比值进行量化。根据欧洲老年人肌肉疏松症工作组(EWGSOP2)对肌肉疏松症进行了定义:唾液TL的平均值为1.50 T/S单位(95% CI:1.49-1.52)。肌肉疏松症的基线发病率为 13.3%(95% CI:9.8-16.8%)。肌少症的发生率和持续率分别为 6.8%(95% CI:5.0-9.5%)和 7.0%(95% CI:5.1-9.6%)。结果显示,横截面上,TL每下降一个标准差,患肌肉疏松症的几率就会增加(OR = 1.31;95% CI:1.03-1.67),而前瞻性上,TL每下降一个标准差,患肌肉疏松症的发生率(RRR = 1.55;95% CI:1.06-2.25)和持续率(RRR = 1.50;95% CI:1.01-2.24)就会增加:结论:TL较短的老年人发生和持续性肌少症的比例较高。有必要采取干预措施来延缓老年人TL的下降。还需要进一步的转化研究来阐明运动或饮食对端粒区DNA修复的影响及其与肌肉疏松症的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Archives of Medical Research
Archives of Medical Research 医学-医学:研究与实验
CiteScore
12.50
自引率
0.00%
发文量
84
审稿时长
28 days
期刊介绍: Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.
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