Aquaporins in colorectal cancer: exploring their role in tumorigenesis, metastasis, and drug response.

IF 3.4 3区生物学 Q3 CELL BIOLOGY

Human Cell Pub Date : 2024-07-01 Epub Date: 2024-05-29 DOI:10.1007/s13577-024-01078-7

Maryam Azimi Mohammadabadi, Ali Moazzeni, Leila Jafarzadeh, Fatemeh Faraji, Amir Hossein Mansourabadi, Elahe Safari

{"title":"Aquaporins in colorectal cancer: exploring their role in tumorigenesis, metastasis, and drug response.","authors":"Maryam Azimi Mohammadabadi, Ali Moazzeni, Leila Jafarzadeh, Fatemeh Faraji, Amir Hossein Mansourabadi, Elahe Safari","doi":"10.1007/s13577-024-01078-7","DOIUrl":null,"url":null,"abstract":"<p><p>Aquaporins (AQPs) are small, integral proteins facilitating water transport across plasma cell membranes in response to osmotic gradients. This family has 13 unique members (AQP0-12), which can also transport glycerol, urea, gases, and other salute small molecules. AQPs play a crucial role in the regulation of different cellular processes, including metabolism, migration, immunity, barrier function, and angiogenesis. These proteins are found to aberrantly overexpress in various cancers, including colorectal cancer (CRC). Growing evidence has explored AQPs as a potential diagnostic biomarker and therapeutic target in different cancers. However, there is no comprehensive review compiling the available information on the crucial role of AQPs in the context of colorectal cancer. This review highlights the significance of AQPs as the biomarker and regulator of tumor cells metabolism. In addition, the proliferation, angiogenesis, and metastasis of tumor cells related to AQPs expression as well as function are discussed. Understanding the AQPs prominent role in chemotherapy resistance is of great importance clinically.</p>","PeriodicalId":49194,"journal":{"name":"Human Cell","volume":" ","pages":"917-930"},"PeriodicalIF":3.4000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Cell","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s13577-024-01078-7","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/29 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Aquaporins (AQPs) are small, integral proteins facilitating water transport across plasma cell membranes in response to osmotic gradients. This family has 13 unique members (AQP0-12), which can also transport glycerol, urea, gases, and other salute small molecules. AQPs play a crucial role in the regulation of different cellular processes, including metabolism, migration, immunity, barrier function, and angiogenesis. These proteins are found to aberrantly overexpress in various cancers, including colorectal cancer (CRC). Growing evidence has explored AQPs as a potential diagnostic biomarker and therapeutic target in different cancers. However, there is no comprehensive review compiling the available information on the crucial role of AQPs in the context of colorectal cancer. This review highlights the significance of AQPs as the biomarker and regulator of tumor cells metabolism. In addition, the proliferation, angiogenesis, and metastasis of tumor cells related to AQPs expression as well as function are discussed. Understanding the AQPs prominent role in chemotherapy resistance is of great importance clinically.

Abstract Image

查看原文本刊更多论文

大肠癌中的水蒸发蛋白：探索它们在肿瘤发生、转移和药物反应中的作用。

水蒸发蛋白（AQPs）是一种小型、完整的蛋白质，可在渗透梯度的作用下促进水分在质细胞膜上的运输。该家族有 13 个独特的成员（AQP0-12），它们还能转运甘油、尿素、气体和其他礼液小分子。AQPs 在调节新陈代谢、迁移、免疫、屏障功能和血管生成等不同细胞过程中发挥着至关重要的作用。在包括结直肠癌（CRC）在内的各种癌症中，这些蛋白都会异常过表达。越来越多的证据表明，AQPs 是不同癌症的潜在诊断生物标志物和治疗靶点。然而，目前还没有一篇全面的综述汇集了关于 AQPs 在结直肠癌中的关键作用的现有信息。本综述强调了 AQPs 作为生物标志物和肿瘤细胞代谢调节剂的重要意义。此外，还讨论了与 AQPs 表达和功能有关的肿瘤细胞增殖、血管生成和转移。了解 AQPs 在化疗耐药性中的突出作用在临床上具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Human Cell CELL BIOLOGY-

CiteScore

5.90

自引率

2.30%

发文量

176

审稿时长

4.5 months

期刊介绍： Human Cell is the official English-language journal of the Japan Human Cell Society. The journal serves as a forum for international research on all aspects of the human cell, encompassing not only cell biology but also pathology, cytology, and oncology, including clinical oncology. Embryonic stem cells derived from animals, regenerative medicine using animal cells, and experimental animal models with implications for human diseases are covered as well. Submissions in any of the following categories will be considered: Research Articles, Cell Lines, Rapid Communications, Reviews, and Letters to the Editor. A brief clinical case report focusing on cellular responses to pathological insults in human studies may also be submitted as a Letter to the Editor in a concise and short format. Not only basic scientists but also gynecologists, oncologists, and other clinical scientists are welcome to submit work expressing new ideas or research using human cells.