Risk factors and treatment outcome of smear positive pulmonary tuberculosis patients: A five-year study in the North of Iran.

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI:10.22088/cjim.15.2.347

Roghieh Golsha, Mahdi Mazandarani, Ahmad Sohrabi, Hesamaddin Shirzad-Aski, Hamidreza Kamalinia, Atefeh Rezaeifar, Mandana Fattahi

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Abstract

Background: It is essential to constantly review the risk factors and treatment outcomes of tuberculosis (TB). This study evaluated some important risk factors of TB over five years.

Methods: Between 2013 and 2018, all available information and possible risk factors related to TB patients were analyzed from the TB registry program of the health district of Gorgan, Iran.

Results: Among 349 TB patients, 194 (55.59%) were males and 167 (47.85%) had at least a comorbidity. The death rate was higher in the age group more than 65 years (p < 0.001), the low-educated group (P = 0.012), and patients with underlying diseases, especially diabetes (p < 0.001). In total, univariate and multivariate statistical analyzes showed that having comorbidity (OR = 4.34; 95% CI 1.49 - 13.49), as well as, being jobless (OR = 3.07; 95% CI 1.19 - 8.59) were the main factors influencing the adverse events.

Conclusion: According to the study, aging, underlying diseases, and cultural poverty include a higher share of the main risk factors for active TB and/or treatment outcomes. By considering these risk factors and training the medical staff continually, we can reduce the time of TB diagnosis, and prevent it from spreading.

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涂片阳性肺结核患者的风险因素和治疗结果：伊朗北部一项为期五年的研究。

背景：不断审查结核病（TB）的风险因素和治疗结果至关重要。本研究评估了五年来结核病的一些重要风险因素：2013年至2018年期间，伊朗戈尔甘卫生区结核病登记项目分析了与结核病患者相关的所有可用信息和可能的风险因素：在 349 名肺结核患者中，194 人（55.59%）为男性，167 人（47.85%）至少患有一种并发症。65 岁以上年龄组（P < 0.001）、低学历组（P = 0.012）和患有基础疾病（尤其是糖尿病）的患者死亡率较高（P < 0.001）。单变量和多变量统计分析结果显示，合并症（OR = 4.34；95% CI 1.49 - 13.49）和无业（OR = 3.07；95% CI 1.19 - 8.59）是不良事件的主要影响因素：研究结果表明，在活动性肺结核和/或治疗结果的主要风险因素中，老龄化、潜在疾病和文化贫困所占比例较高。通过考虑这些风险因素并对医务人员进行持续培训，我们可以缩短结核病的诊断时间，并防止其传播。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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