Evaluating the incidence of complications among people with diabetes according to age of onset: Findings from the UK Biobank

IF 3.2 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Diabetic Medicine Pub Date : 2024-05-29 DOI:10.1111/dme.15349

Seyedeh Forough Sajjadi, Julian W. Sacre, Bendix Carstensen, Sergio Ruiz-Carmona, Jonathan E. Shaw, Dianna J. Magliano

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引用次数: 0

Abstract

Aims

To examine the impact of current age, age at diagnosis, and duration of diabetes on the incidence rate of complications among people with type 2 diabetes.

Methods

Baseline data from 19,327 individuals with type 2 diabetes in the UK Biobank were analysed. Poisson regression was used to model incidence rates by current age, age at diagnosis, and duration of diabetes for the following outcomes: myocardial infarction (MI), heart failure (HF), stroke, end-stage kidney diseases (ESKD), chronic kidney diseases (CKD), liver diseases, depression, and anxiety.

Results

The mean age at baseline was 60.2 years, and median follow-up was 13.9 years. Diabetes duration was significantly longer among those with younger-onset type 2 diabetes (diagnosed at <40 years) compared to later-onset type 2 diabetes (diagnosed at ≥40 years), 16.2 and 5.3 years, respectively. Incidence rates of MI, HF, stroke, and CKD had strong positive associations with age and duration of diabetes, whereas incidence rates of ESKD liver diseases, and anxiety mainly depended on duration of diabetes. The incidence rates of depression showed minor variation by age and duration of diabetes and were highest among those diagnosed at earlier ages. No clear evidence of an effect of age of onset of diabetes on risk of complications was apparent after accounting for current age and duration of diabetes.

Conclusions

Our study indicates age at diagnosis of diabetes does not significantly impact the incidence of complications, independently of the duration of diabetes. Instead, complications are primarily influenced by current age and diabetes duration.

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根据发病年龄评估糖尿病患者并发症的发生率：英国生物库的研究结果。

目的：研究当前年龄、确诊年龄和糖尿病持续时间对 2 型糖尿病患者并发症发病率的影响：分析了英国生物库中 19,327 名 2 型糖尿病患者的基线数据。方法：对英国生物库中 19,327 名 2 型糖尿病患者的基线数据进行了分析，采用泊松回归法建立了当前年龄、确诊年龄和糖尿病持续时间与以下结果相关的发病率模型：心肌梗死（MI）、心力衰竭（HF）、中风、终末期肾病（ESKD）、慢性肾病（CKD）、肝病、抑郁症和焦虑症：基线时的平均年龄为 60.2 岁，中位随访时间为 13.9 年。在发病年龄较小的 2 型糖尿病患者中，糖尿病持续时间明显较长（诊断时年龄为 60.2 岁）：我们的研究表明，诊断糖尿病时的年龄对并发症的发生率影响不大，与糖尿病病程无关。相反，并发症主要受当前年龄和糖尿病病程的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetic Medicine 医学-内分泌学与代谢

CiteScore

7.20

自引率

5.70%

发文量

229

审稿时长

3-6 weeks

期刊介绍： Diabetic Medicine, the official journal of Diabetes UK, is published monthly simultaneously, in print and online editions. The journal publishes a range of key information on all clinical aspects of diabetes mellitus, ranging from human genetic studies through clinical physiology and trials to diabetes epidemiology. We do not publish original animal or cell culture studies unless they are part of a study of clinical diabetes involving humans. Categories of publication include research articles, reviews, editorials, commentaries, and correspondence. All material is peer-reviewed. We aim to disseminate knowledge about diabetes research with the goal of improving the management of people with diabetes. The journal therefore seeks to provide a forum for the exchange of ideas between clinicians and researchers worldwide. Topics covered are of importance to all healthcare professionals working with people with diabetes, whether in primary care or specialist services. Surplus generated from the sale of Diabetic Medicine is used by Diabetes UK to know diabetes better and fight diabetes more effectively on behalf of all people affected by and at risk of diabetes as well as their families and carers.”