Effect of selenium on anti-Tg antibody in patients with autoimmune hypothyroidism: A randomized controlled trial.

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL

Caspian Journal of Internal Medicine Pub Date : 2024-01-01 DOI:10.22088/cjim.15.2.340

Mina AkbariRad, Zahra Mazloum Khorasani, Behnam Beizae, Hossein Ayatollahi, Maryam Emadzadeh, Mehrdad Sarabi, Nikoo Saeedi, Negar Nekooei

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Abstract

Background: The current study intends to assess the impact of oral selenium intake on anti-Tg antibody in individuals with autoimmune hypothyroidism.

Methods: In this double-blinded randomized controlled trial, two groups of 72 autoimmune hypothyroid patients were randomly assigned; one group received levothyroxine (LT4) and oral selenium and the other group was given placebo with LT4. Anti-Tg antibody, free T4, anti-TPO antibody, and TSH were identified in both groups before the treatment and also 3 months after treatment and analysis of data was done by SPSS software.

Results: After the intervention, the average amount of anti-Tg antibody decreased in both of the groups, and this decrease was noticeably greater in the intervention group (P = 0.03). In the intervention group, the TSH level decreased after the intervention (p < 0.05), and the free T4 level increased after the intervention (p < 0.05); the changes in these two variables were statistically significant.

Conclusion: Consumption of selenium, compared to placebo, in patients with autoimmune hypothyroidism drastically reduces the level of anti-Tg antibody, and it significantly increases the free T4 level. Also, there is a greater decrease in the level of TSH compared to the control group.

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硒对自身免疫性甲状腺功能减退症患者抗 Tg 抗体的影响：随机对照试验

研究背景本研究旨在评估口服硒对自身免疫性甲状腺功能减退症患者抗Tg抗体的影响：在这项双盲随机对照试验中，72 名自身免疫性甲状腺功能减退症患者被随机分为两组，一组接受左甲状腺素（LT4）和口服硒，另一组在接受左甲状腺素的同时服用安慰剂。在治疗前和治疗 3 个月后，对两组患者的抗 Tg 抗体、游离 T4、抗TPO 抗体和 TSH 进行检测，并使用 SPSS 软件对数据进行分析：干预后，两组患者的抗 Tg 抗体平均值均有所下降，且干预组的下降幅度明显更大（P = 0.03）。干预组的促甲状腺激素水平在干预后下降（P < 0.05），游离 T4 水平在干预后上升（P < 0.05）；这两个变量的变化具有统计学意义：结论：与安慰剂相比，自身免疫性甲状腺功能减退症患者服用硒能大幅降低抗Tg抗体水平，并显著提高游离T4水平。此外，与对照组相比，促甲状腺激素水平的下降幅度更大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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