Terpenoids of plants from Chloranthaceae family: chemistry, bioactivity, and synthesis†

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2024-09-18 DOI:10.1039/d4np00005f

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引用次数: 0

Abstract

Covering: 1976 to December 2023

Chloranthaceae is comprised of four extant genera (Chloranthus, Sarcandra, Hedyosmum, and Ascarina), totaling about 80 species, many of which have been widely used as herbal medicines for diverse medical purposes. Chloranthaceae plants represent a rich source of structurally interesting and diverse secondary metabolites, with sesquiterpenoids and diterpenoids being the predominant structural types. Lindenane sesquiterpenoids and their oligomers, chemotaxonomical markers of the family Chloranthaceae, have shown a wide spectrum of bioactivities, attracting significant attention from organic chemists and pharmacologists. Recent achievements also demonstrated the research value of two unique structural types in this plant family, sesquiterpenoid–monoterpenoid heterodimers and meroterpenoids. This review systematically summarizes 682 structurally characterized terpenoids from 22 Chloranthaceae plants and their key biological activities as well as the chemical synthesis of selected terpenoids.

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绿茶科植物的萜类化合物：化学、生物活性和合成。

覆盖范围：1976 年至 2023 年 12 月1976 年 12 月至 2023 年 12 月Chloranthaceae 由四个现存属（Chloranthus、Sarcandra、Hedyosmum 和 Ascarina）组成，共有约 80 个物种，其中许多已被广泛用作草药，用于各种医疗目的。氯兰科植物是结构有趣、种类繁多的次生代谢物的丰富来源，其中倍半萜和二萜是主要的结构类型。林丹倍半萜类化合物及其低聚物是氯苋科植物的化学分类标志，具有广泛的生物活性，引起了有机化学家和药理学家的极大关注。最近的研究成果还证明了该植物家族中两种独特结构类型--倍半萜类-单萜类异构体和经络萜类--的研究价值。这篇综述系统地总结了来自 22 种植物的 682 种具有结构特征的萜类化合物及其主要生物活性，以及部分萜类化合物的化学合成。

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.