Foveal thickness and its association with visual acuity in adults born preterm with very low birth weight: A two-country birth cohort study

IF 3 3区 医学 Q1 OPHTHALMOLOGY
Anna P. M. Jørgensen, Maarit Kulmala, Dordi Austeng, Kari Anne I. Evensen, Eero Kajantie, Anna Majander, Tora Sund Morken
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Abstract

Purpose

To explore foveal and parafoveal thickness in adults born preterm with very low birth weight (VLBW) and its association with best-corrected visual acuity (BCVA) and gestational age (GA) compared to adults born at term.

Methods

In a joint study of the Helsinki Study of Very Low Birth Weight Adults (Finland) and the NTNU Low Birth Weight Life study (Norway), 106 VLBW and 143 term-born controls were examined with spectral-domain optical coherence tomography and BCVA at age 31–43 years. Thickness of retinal layers was segmented in the foveal and parafoveal areas of the macula.

Results

The total retinal thickness in the foveal area was thicker in VLBW adults compared with controls; mean (SD): 292.5 μm (28.2) and 272.4 μm (20.2); p < 0.001, and thinner in the parafoveal areas of the macula. These findings could be explained by a thicker inner retinal layer in the foveal area found in VLBW adults compared with controls (mean difference 20.4 μm; CI: 15.0 to 25.9), where a thicker fovea was associated with lower GA, but not BCVA.

Conclusion

Adults born preterm with VLBW had a thicker retina in the foveal area than controls and this was associated with GA, but not with BCVA. These changes seem to be related to a thicker inner retinal layer in VLBW adults. The findings imply that signs of macular underdevelopment are still present in adulthood, but not necessarily related to reduced visual function.

Abstract Image

早产超低体重儿的眼窝厚度及其与视力的关系:两国出生队列研究。
目的:与足月出生的成人相比,探讨早产超低出生体重儿(VLBW)的眼窝和眼窝旁厚度及其与最佳矫正视力(BCVA)和胎龄(GA)的关系:在赫尔辛基超低出生体重儿研究(芬兰)和挪威 NTNU 低出生体重儿生命研究(挪威)的一项联合研究中,106 名超低出生体重儿和 143 名足月儿对照组在 31-43 岁时接受了光谱域光学相干断层扫描和 BCVA 检查。对黄斑部的眼窝区和眼窝旁区的视网膜层厚度进行了分割:结果:与对照组相比,VLBW 成人的眼窝区视网膜总厚度更厚;平均值(标清):292.5 μm (28.2) 和 272.4 μm (20.2);P 结论:VLBW 成人的视网膜总厚度更厚:与对照组相比,VLBW早产儿的视网膜眼窝区更厚,这与GA有关,但与BCVA无关。这些变化似乎与早产儿视网膜内层较厚有关。这些研究结果表明,黄斑发育不全的迹象在成年后仍然存在,但不一定与视觉功能下降有关。
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来源期刊
Acta Ophthalmologica
Acta Ophthalmologica 医学-眼科学
CiteScore
7.60
自引率
5.90%
发文量
433
审稿时长
6 months
期刊介绍: Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.
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