Endocrine Aspects of Pain Pathophysiology: Focus on Adipose Tissue.

IF 3.2 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Neuroendocrinology Pub Date : 2024-05-28 DOI:10.1159/000539531

Mete Ozcan, Ahmet Ayar

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引用次数: 0

Abstract

Background: Multiple factors, including neurobiological, hormonal, psychological, and social/cultural norms, influence the manner in which individuals experience pain. Adipose tissue, once considered solely an energy storage site, has been recognized as a significant endocrine organ that produces and releases a range of hormones and cytokines. In recent years, research has highlighted the role of adipose tissue and its endocrine factors in the pathophysiology of pain.

Summary: This narrative review aimed to provide a comprehensive overview of the current knowledge on the endocrine aspects of pain pathophysiology, with a specific focus on adipose tissue. We examine the role of adipokines released by adipose tissue, such as leptin, adiponectin, resistin, visfatin, asprosin in pain perception and response. We also explore the clinical implications of these findings, including the potential for personalized pain management based on endocrine factors and adipose tissue.

Key messages: Overall, given this background, this review intended to highlight the importance of understanding the endocrine aspects of pain pathophysiology, particularly focusing on the role of adipose tissue, in the development of chronic pain and adipokines. Better understanding the role of adipokines in pain modulation might have therapeutic implications by providing novel targets for addressing underlying mechanism rather than directly focusing on symptoms for chronic pain, particularly in obese individuals.

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疼痛病理生理学的内分泌方面：关注脂肪组织。

背景：包括神经生物学、荷尔蒙、心理学和社会/文化规范在内的多种因素会影响个人体验疼痛的方式。脂肪组织曾被认为只是一个能量储存场所，但现在已被认为是一个重要的内分泌器官，能产生和释放一系列激素和细胞因子。近年来，研究强调了脂肪组织及其内分泌因素在疼痛病理生理学中的作用。摘要：这篇叙述性综述旨在全面概述目前有关疼痛病理生理学内分泌方面的知识，尤其侧重于脂肪组织。我们重点研究了脂肪组织释放的脂肪因子在疼痛感知和反应中的作用，如瘦素、脂肪连通素、抵抗素、粘蛋白、阿斯普罗素等。我们还探讨了这些发现的临床意义，包括根据内分泌因素和脂肪组织进行个性化疼痛管理的可能性：总体而言，鉴于上述背景，本综述旨在强调了解疼痛病理生理学中内分泌方面的重要性，尤其是关注脂肪组织在慢性疼痛和脂肪因子发展中的作用。更好地了解脂肪因子在疼痛调节中的作用可能具有治疗意义，因为它提供了解决潜在机制的新目标，而不是直接关注慢性疼痛的症状，尤其是肥胖者的症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroendocrinology 医学-内分泌学与代谢

CiteScore

8.30

自引率

2.40%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Neuroendocrinology'' publishes papers reporting original research in basic and clinical neuroendocrinology. The journal explores the complex interactions between neuronal networks and endocrine glands (in some instances also immunecells) in both central and peripheral nervous systems. Original contributions cover all aspects of the field, from molecular and cellular neuroendocrinology, physiology, pharmacology, and the neuroanatomy of neuroendocrine systems to neuroendocrine correlates of behaviour, clinical neuroendocrinology and neuroendocrine cancers. Readers also benefit from reviews by noted experts, which highlight especially active areas of current research, and special focus editions of topical interest.