Pathophysiology of cutaneous T-cell lymphomas: Perspective from a French referral centre

IF 3.3 4区 医学 Q3 IMMUNOLOGY
Adèle De Masson , Ingrid Lazaridou , Hélène Moins-Teisserenc , Caroline Ram-Wolff , Jérôme Giustiniani , Martine Bagot , Maxime Battistella , Armand Bensussan
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引用次数: 0

Abstract

Cutaneous T-cell lymphomas (CTCL) are a diverse group of malignant blood disorders characterized by initial skin infiltration, and sometimes, tumor spreading to lymph nodes, blood, and viscera. Mycosis fungoides is the most common form. Sézary syndrome is a distinctive form of CTCL marked by a significant presence of circulating tumor cells in peripheral blood. These diseases are characterized by the plasticity and heterogeneity of the tumor cells in the different tissue compartments, and a difficulty in identifying these tumor cells for diagnostic purposes and therapeutic monitoring. Progress has been made in the understanding of the pathophysiology of these diseases in recent years, and we provide here a review of these advancements.

皮肤 T 细胞淋巴瘤的病理生理学:来自法国转诊中心的视角。
皮肤T细胞淋巴瘤(CTCL)是一组种类繁多的恶性血液疾病,其特点是最初的皮肤浸润,有时肿瘤会扩散到淋巴结、血液和内脏。放线菌病是最常见的一种。塞扎里综合征(Sézary syndrome)是一种独特的 CTCL,其特征是外周血中存在大量循环肿瘤细胞。这些疾病的特点是肿瘤细胞在不同组织区划中具有可塑性和异质性,而且难以识别这些肿瘤细胞以进行诊断和治疗监测。近年来,人们在了解这些疾病的病理生理学方面取得了进展,我们在此对这些进展进行综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Immunology letters
Immunology letters 医学-免疫学
CiteScore
7.60
自引率
0.00%
发文量
86
审稿时长
44 days
期刊介绍: Immunology Letters provides a vehicle for the speedy publication of experimental papers, (mini)Reviews and Letters to the Editor addressing all aspects of molecular and cellular immunology. The essential criteria for publication will be clarity, experimental soundness and novelty. Results contradictory to current accepted thinking or ideas divergent from actual dogmas will be considered for publication provided that they are based on solid experimental findings. Preference will be given to papers of immediate importance to other investigators, either by their experimental data, new ideas or new methodology. Scientific correspondence to the Editor-in-Chief related to the published papers may also be accepted provided that they are short and scientifically relevant to the papers mentioned, in order to provide a continuing forum for discussion.
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