Biomonitoring Study of Urinary Bisphenol A Levels and Impact of Bottle-Feeding Practices Among Infants and Children From Northern India.

IF 1.7 4区医学 Q2 PEDIATRICS

Indian pediatrics Pub Date : 2024-07-15 Epub Date: 2024-05-25

Prabakaran Gangadaran, Bhavneet Bharti, Savita Verma Attri, Vivek Singh Malik, Ajay Patial

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引用次数: 0

Abstract

Objectives: To compare the urinary bisphenol A (BPA) levels in bottle-fed and never bottle-fed infants and under-five children and to determine the impact of bottle-feeding practices and sociodemographic factors on urinary BPA levels.

Methods: A community-based cross-sectional study was carried out on children aged between 2 to 60 months attending the Anganwadi centres in Chandigarh.

Results: Urine samples were collected from 184 children, out of which 94.56% (n = 174) children had detectable urinary BPA levels. The mean (SD) BPA level was 2.74 (2.60) ng/ml and BPA was detected in 93.9% of 'ever' bottle-fed children (n = 93/99) and 95.3% of 'never' bottle-fed children (n = 81/85) (P = 0.69). On multivariate regression analysis, there were no significant predictors for high (≥ 75th percentile) urinary BPA levels. Still, the odds of urinary BPA levels ≥75th percentile showed higher trend for significance among children from middle/higher socioeconomic background in reference to lower socioeconomic stratum (adjusted OR 7.02; 95% CI 1.24, 133.25; P = 0.07) and among children whose feeding bottles were brushed once or twice daily in reference to group with no daily brushing (adjusted OR 3.92, 95% CI 0.95, 20.56; P = 0.07).

Conclusions: Although feeding with plastic bottle did not emerge as a statistically significant risk factor for BPA exposure, yet detection of BPA levels among majority of study children signals urgent need for unmasking exposure to other sources given the potential long-term toxicity of BPA among infants and young children.

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印度北部婴幼儿尿液中双酚 A 含量及奶瓶喂养方式影响的生物监测研究

研究目的比较用奶瓶喂养和从未用奶瓶喂养的婴儿和五岁以下儿童尿液中的双酚 A (BPA) 含量，并确定奶瓶喂养方式和社会人口因素对尿液中双酚 A 含量的影响：方法：对昌迪加尔Anganwadi中心2至60个月大的儿童进行了一项基于社区的横断面研究：收集了 184 名儿童的尿液样本，其中 94.56%（n = 174）的儿童尿液中可检测到双酚 A 含量。93.9%的 "曾经 "用奶瓶喂养的儿童（n = 93/99）和 95.3%的 "从未 "用奶瓶喂养的儿童（n = 81/85）（P = 0.69）检测到双酚 A。在多变量回归分析中，尿液中双酚 A 含量高（≥ 75 百分位数）的预测因素并不明显。不过，与社会经济地位较低的阶层相比，来自中等/较高社会经济背景的儿童尿液中双酚A水平≥75百分位数的几率显示出更高的显著性趋势（调整后OR值为7.02；95% CI为1.24，133.25；P = 0.07），与每天不刷洗奶瓶的儿童相比，每天刷洗奶瓶1次或2次的儿童尿液中双酚A水平≥75百分位数的几率显示出更高的显著性趋势（调整后OR值为3.92，95% CI为0.95，20.56；P = 0.07）：尽管使用塑料奶瓶喂养并不是暴露于双酚A的一个具有统计学意义的风险因素，但鉴于双酚A在婴幼儿中的潜在长期毒性，在大多数研究儿童中检测到双酚A水平表明，迫切需要消除其他来源的暴露。

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来源期刊

Indian pediatrics 医学-小儿科

CiteScore

3.30

自引率

8.70%

发文量

344

审稿时长

3-8 weeks

期刊介绍： The general objective of Indian Pediatrics is "To promote the science and practice of Pediatrics." An important guiding principle has been the simultaneous need to inform, educate and entertain the target audience. The specific key objectives are: -To publish original, relevant, well researched peer reviewed articles on issues related to child health. -To provide continuing education to support informed clinical decisions and research. -To foster responsible and balanced debate on controversial issues that affect child health, including non-clinical areas such as medical education, ethics, law, environment and economics. -To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible and enjoyable to read.