Planar Cell Polarity Signaling: Coordinated Crosstalk for Cell Orientation.

IF 2.2 Q3 DEVELOPMENTAL BIOLOGY

Journal of Developmental Biology Pub Date : 2024-04-29 DOI:10.3390/jdb12020012

Sandeep Kacker, Varuneshwar Parsad, Naveen Singh, Daria Hordiichuk, Stacy Alvarez, Mahnoor Gohar, Anshu Kacker, Sunil Kumar Rai

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引用次数: 0

Abstract

The planar cell polarity (PCP) system is essential for positioning cells in 3D networks to establish the proper morphogenesis, structure, and function of organs during embryonic development. The PCP system uses inter- and intracellular feedback interactions between components of the core PCP, characterized by coordinated planar polarization and asymmetric distribution of cell populations inside the cells. PCP signaling connects the anterior-posterior to left-right embryonic plane polarity through the polarization of cilia in the Kupffer's vesicle/node in vertebrates. Experimental investigations on various genetic ablation-based models demonstrated the functions of PCP in planar polarization and associated genetic disorders. This review paper aims to provide a comprehensive overview of PCP signaling history, core components of the PCP signaling pathway, molecular mechanisms underlying PCP signaling, interactions with other signaling pathways, and the role of PCP in organ and embryonic development. Moreover, we will delve into the negative feedback regulation of PCP to maintain polarity, human genetic disorders associated with PCP defects, as well as challenges associated with PCP.

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平面细胞极性信号：细胞定向的协调串扰

在胚胎发育过程中，平面细胞极性（PCP）系统对细胞在三维网络中的定位至关重要，以建立器官的正确形态发生、结构和功能。PCP 系统利用 PCP 核心成分之间的细胞间和细胞内反馈相互作用，其特点是协调的平面极性化和细胞内细胞群的不对称分布。在脊椎动物中，PCP 信号通过 Kupffer 囊泡/结节中纤毛的极化将前后胚胎平面极性与左右胚胎平面极性联系起来。基于各种基因消融模型的实验研究证明了 PCP 在平面极性化和相关遗传疾病中的功能。本综述旨在全面概述 PCP 信号传导的历史、PCP 信号传导途径的核心成分、PCP 信号传导的分子机制、与其他信号传导途径的相互作用以及 PCP 在器官和胚胎发育中的作用。此外，我们还将深入探讨 PCP 维持极性的负反馈调节、与 PCP 缺陷相关的人类遗传疾病以及与 PCP 相关的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Developmental Biology Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

4.10

自引率

18.50%

发文量

审稿时长

11 weeks

期刊介绍： The Journal of Developmental Biology (ISSN 2221-3759) is an international, peer-reviewed, quick-refereeing, open access journal, which publishes reviews, research papers and communications on the development of multicellular organisms at the molecule, cell, tissue, organ and whole organism levels. Our aim is to encourage researchers to effortlessly publish their new findings or concepts rapidly in an open access medium, overseen by their peers. There is no restriction on the length of the papers; the full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. Journal of Developmental Biology focuses on: -Development mechanisms and genetics -Cell differentiation -Embryonal development -Tissue/organism growth -Metamorphosis and regeneration of the organisms. It involves many biological fields, such as Molecular biology, Genetics, Physiology, Cell biology, Anatomy, Embryology, Cancer research, Neurobiology, Immunology, Ecology, Evolutionary biology.