Standard tests of haemostasis do not predict elevated thromboelastographic maximum amplitude, an index of hypercoagulability, in sick dogs

IF 1.7 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice Pub Date : 2024-05-28 DOI:10.1111/jsap.13741

R. C. Clarkin-Breslin, N. V. Chalifoux, Y. Buriko

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Abstract

Objectives

To compare standard tests of haemostasis in hypercoagulable and normocoagulable sick dogs as identified by thromboelastography.

Materials and Methods

We compared prothrombin time, activated partial thromboplastin time, D-dimers, packed red blood cell volume and platelet counts in client-owned sick dogs with hypercoagulable (n = 36) and normocoagulable (n = 35) states as identified by thromboelastography maximum amplitude above or within the established reference interval, respectively.

Results

Seventy-one dogs were included. Thirty-six dogs were hypercoagulable and 35 were normocoagulable on thromboelastography. Using multivariable linear models, prothrombin time, activated partial thromboplastin time and D-dimers were not associated with hypercoagulability. Platelet counts and packed red blood cell volume were significantly associated with hypercoagulability.

Clinical Significance

Prothrombin time, activated partial thromboplastin time and D-dimers were not useful in the identification of hypercoagulability in dogs as defined by thromboelastography.

查看原文本刊更多论文

标准止血测试无法预测病犬血栓弹性图最大振幅（一种高凝状态指数）的升高。

目的比较血栓弹力图确定的高凝状态和正常凝状态病犬的止血标准测试：我们比较了客户饲养的病犬的凝血酶原时间、活化部分凝血活酶时间、D-二聚体、充盈红细胞体积和血小板计数：结果：共纳入 71 只狗。结果：共纳入 71 只犬，其中 36 只犬血栓弹力图显示为高凝状态，35 只犬血栓弹力图显示为正常凝状态。使用多变量线性模型，凝血酶原时间、活化部分凝血活酶时间和 D-二聚体与高凝状态无关。血小板计数和充盈红细胞体积与高凝状态有显著相关性：临床意义：凝血酶原时间、活化部分凝血活酶时间和 D-二聚体对通过血栓弹力图确定犬的高凝状态没有帮助。

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来源期刊

Journal of Small Animal Practice 农林科学-兽医学

CiteScore

3.30

自引率

6.20%

发文量

117

审稿时长

12-24 weeks

期刊介绍： Journal of Small Animal Practice (JSAP) is a monthly peer-reviewed publication integrating clinical research papers and case reports from international sources, covering all aspects of medicine and surgery relating to dogs, cats and other small animals. These papers facilitate the dissemination and implementation of new ideas and techniques relating to clinical veterinary practice, with the ultimate aim of promoting best practice. JSAP publishes high quality original articles, as well as other scientific and educational information. New developments are placed in perspective, encompassing new concepts and peer commentary. The target audience is veterinarians primarily engaged in the practise of small animal medicine and surgery. In addition to original articles, JSAP will publish invited editorials (relating to a manuscript in the same issue or a topic of current interest), review articles, which provide in-depth discussion of important clinical issues, and other scientific and educational information from around the world. The final decision on publication of a manuscript rests with the Editorial Board and ultimately with the Editor. All papers, regardless of type, represent the opinion of the authors and not necessarily that of the Editor, the Association or the Publisher. The Journal of Small Animal Practice is published on behalf of the British Small Animal Veterinary Association and is also the official scientific journal of the World Small Animal Veterinary Association