The Role of Bacterial Extracellular Membrane Nanovesicles in Atherosclerosis: Unraveling a Potential Trigger.

IF 5.7 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Current Atherosclerosis Reports Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI:10.1007/s11883-024-01206-6

Konstantin A Lusta, Volha I Summerhill, Victoria A Khotina, Vasily N Sukhorukov, Victor Y Glanz, Alexander N Orekhov

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Abstract

Purpose of review: In this review, we explore the intriguing and evolving connections between bacterial extracellular membrane nanovesicles (BEMNs) and atherosclerosis development, highlighting the evidence on molecular mechanisms by which BEMNs can promote the athero-inflammatory process that is central to the progression of atherosclerosis.

Recent findings: Atherosclerosis is a chronic inflammatory disease primarily driven by metabolic and lifestyle factors; however, some studies have suggested that bacterial infections may contribute to the development of both atherogenesis and inflammation in atherosclerotic lesions. In particular, the participation of BEMNs in atherosclerosis pathogenesis has attracted special attention. We provide some general insights into how the immune system responds to potential threats such as BEMNs during the development of atherosclerosis. A comprehensive understanding of contribution of BEMNs to atherosclerosis pathogenesis may lead to the development of targeted interventions for the prevention and treatment of the disease.

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细菌胞外膜纳米颗粒在动脉粥样硬化中的作用：揭开潜在诱因的面纱

综述的目的：在这篇综述中，我们探讨了细菌胞外膜纳米颗粒（BEMNs）与动脉粥样硬化发展之间耐人寻味且不断发展的联系，强调了BEMNs可促进动脉粥样硬化进展的核心--动脉粥样硬化炎症过程的分子机制的证据：动脉粥样硬化是一种慢性炎症性疾病，主要由代谢和生活方式因素驱动；然而，一些研究表明，细菌感染可能有助于动脉粥样硬化病变中动脉粥样硬化的发生和炎症的发展。特别是，BEMNs 在动脉粥样硬化发病机制中的参与引起了特别关注。我们就动脉粥样硬化发展过程中免疫系统如何应对 BEMNs 等潜在威胁提供了一些一般性见解。全面了解 BEMNs 在动脉粥样硬化发病机制中的作用可能有助于开发有针对性的干预措施来预防和治疗该疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Atherosclerosis Reports 医学-

CiteScore

9.00

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of this journal is to systematically provide expert views on current basic science and clinical advances in the field of atherosclerosis and highlight the most important developments likely to transform the field of cardiovascular prevention, diagnosis, and treatment. We accomplish this aim by appointing major authorities to serve as Section Editors who select leading experts from around the world to provide definitive reviews on key topics and papers published in the past year. We also provide supplementary reviews and commentaries from well-known figures in the field. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.