Efficiency of conversion surgery for esophageal squamous cell carcinoma with solitary abdominal para-aortic lymph node metastasis.

IF 1.7 4区医学 Q2 SURGERY

Surgery Today Pub Date : 2024-12-01 Epub Date: 2024-05-27 DOI:10.1007/s00595-024-02872-4

Takashi Shigeno, Daisuke Kajiyama, Kazuma Sato, Naoto Fujiwara, Yusuke Kinugasa, Hiroyuki Daiko, Takeo Fujita

{"title":"Efficiency of conversion surgery for esophageal squamous cell carcinoma with solitary abdominal para-aortic lymph node metastasis.","authors":"Takashi Shigeno, Daisuke Kajiyama, Kazuma Sato, Naoto Fujiwara, Yusuke Kinugasa, Hiroyuki Daiko, Takeo Fujita","doi":"10.1007/s00595-024-02872-4","DOIUrl":null,"url":null,"abstract":"Purpose: Abdominal para-aortic lymph nodes (PANs) are sites of distant metastasis in esophageal squamous cell cancer (ESCC). The prognosis of patients with Stage IVB ESCC and abdominal PAN metastasis is extremely poor. However, chemotherapy for ESCC has recently been developed, and the effectiveness of combined induction therapy and conversion surgery remains unclear. The primary objective of this study was to evaluate the short- and long-term outcomes of conversion surgery for ESCC and solitary abdominal PAN metastases after induction therapy.Methods: Thirteen patients who underwent conversion esophagectomy for cStage IVB ESCC with solitary abdominal PAN metastasis after induction therapy between January 2017 and October 2022 at our institution were enrolled. The short- and long-term outcomes of conversion surgery were retrospectively evaluated.Results: Three patients (23.1%) had pathological abdominal PAN metastasis, and six patients (46.2%) without pathological abdominal PAN metastasis showed that chemotherapy eliminated the tumors in the abdominal PAN. Three patients (23.1%) had postoperative complications of Clavien-Dindo grade II or higher. The 3-year overall and recurrence-free survival rates were 83.1% and 51.3%, respectively.Conclusions: Our findings showed that conversion surgery for ESCC and solitary abdominal PAN metastasis led to a good prognosis when induction therapy was successful.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"1490-1497"},"PeriodicalIF":1.7000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Surgery Today","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00595-024-02872-4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/27 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Abdominal para-aortic lymph nodes (PANs) are sites of distant metastasis in esophageal squamous cell cancer (ESCC). The prognosis of patients with Stage IVB ESCC and abdominal PAN metastasis is extremely poor. However, chemotherapy for ESCC has recently been developed, and the effectiveness of combined induction therapy and conversion surgery remains unclear. The primary objective of this study was to evaluate the short- and long-term outcomes of conversion surgery for ESCC and solitary abdominal PAN metastases after induction therapy.

Methods: Thirteen patients who underwent conversion esophagectomy for cStage IVB ESCC with solitary abdominal PAN metastasis after induction therapy between January 2017 and October 2022 at our institution were enrolled. The short- and long-term outcomes of conversion surgery were retrospectively evaluated.

Results: Three patients (23.1%) had pathological abdominal PAN metastasis, and six patients (46.2%) without pathological abdominal PAN metastasis showed that chemotherapy eliminated the tumors in the abdominal PAN. Three patients (23.1%) had postoperative complications of Clavien-Dindo grade II or higher. The 3-year overall and recurrence-free survival rates were 83.1% and 51.3%, respectively.

Conclusions: Our findings showed that conversion surgery for ESCC and solitary abdominal PAN metastasis led to a good prognosis when induction therapy was successful.

Abstract Image

查看原文本刊更多论文

食管鳞状细胞癌伴有单发腹主动脉旁淋巴结转移的转化手术效率。

目的：腹主动脉旁淋巴结（PAN）是食管鳞状细胞癌（ESCC）的远处转移部位。IVB 期 ESCC 且腹部 PAN 转移的患者预后极差。然而，针对 ESCC 的化疗是最近才发展起来的，而联合诱导治疗和转化手术的有效性仍不明确。本研究的主要目的是评估诱导治疗后 ESCC 和单发腹腔 PAN 转移转化手术的短期和长期疗效：入组 13 例于 2017 年 1 月至 2022 年 10 月期间在我院接受诱导治疗后因 cStage IVB ESCC 伴单发腹腔 PAN 转移而接受转化食管切除术的患者。对转换手术的短期和长期结果进行了回顾性评估：3例患者（23.1%）有病理性腹腔PAN转移，6例患者（46.2%）无病理性腹腔PAN转移，化疗消除了腹腔PAN中的肿瘤。3名患者（23.1%）术后出现了克拉维恩-丁多（Clavien-Dindo）II级或以上的并发症。3年总生存率和无复发生存率分别为83.1%和51.3%：我们的研究结果表明，在诱导治疗成功的情况下，ESCC和单发腹腔PAN转移瘤的转化手术预后良好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Surgery Today 医学-外科

CiteScore

4.90

自引率

4.00%

发文量

208

审稿时长

1 months

期刊介绍： Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.