A close-up of regulatory networks and signaling pathways of MKK5 in biotic and abiotic stresses.

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Ali Movahedi, Delight Hwarari, Raphael Dzinyela, Siyi Ni, Liming Yang
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引用次数: 0

Abstract

Mitogen-activated protein Kinase Kinase 5 (MKK5) is a central hub in the complex phosphorylation chain reaction of the Mitogen-activated protein kinases (MAPK) cascade, regulating plant responses to biotic and abiotic stresses. This review manuscript aims to provide a comprehensive analysis of the regulatory mechanism of the MKK5 involved in stress adaptation. This review will delve into the intricate post-transcriptional and post-translational modifications of the MKK5, discussing how they affect its expression, activity, and subcellular localization in response to stress signals. We also discuss the integration of the MKK5 into complex signaling pathways, orchestrating plant immunity against pathogens and its modulating role in regulating abiotic stresses, such as: drought, cold, heat, and salinity, through the phytohormonal signaling pathways. Furthermore, we highlight potential applications of the MKK5 for engineering stress-resilient crops and provide future perspectives that may pave the way for future studies. This review manuscript aims to provide valuable insights into the mechanisms underlying MKK5 regulation, bridge the gap from numerous previous findings, and offer a firm base in the knowledge of MKK5, its regulating roles, and its involvement in environmental stress regulation.

MKK5在生物和非生物胁迫中的调控网络和信号通路特写。
丝裂原活化蛋白激酶 5(MKK5)是丝裂原活化蛋白激酶(MAPK)级联复杂的磷酸化链式反应的中心枢纽,调节植物对生物和非生物胁迫的反应。本综述旨在全面分析 MKK5 参与胁迫适应的调控机制。本综述将深入探讨 MKK5 错综复杂的转录后和翻译后修饰,讨论它们如何影响 MKK5 的表达、活性和亚细胞定位,以应对胁迫信号。我们还讨论了 MKK5 与复杂信号通路的整合、协调植物对病原体的免疫以及通过植物激素信号通路在调节干旱、寒冷、高温和盐度等非生物胁迫中的调节作用。此外,我们还强调了 MKK5 在工程化抗逆作物方面的潜在应用,并提供了可能为未来研究铺平道路的前景。本综述手稿旨在为 MKK5 的调控机制提供有价值的见解,弥合之前众多研究结果的差距,并为 MKK5 及其调控作用以及参与环境胁迫调控提供坚实的知识基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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