Macromolecular Nano-Assemblies for Enhancing the Effect of Oxygen-Dependent Photodynamic Therapy Against Hypoxic Tumors

IF 3.7 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2024-05-26 DOI:10.1002/chem.202401700

Peipei Zhang, Meng Cheng, Yael Levi-Kalisman, Uri Raviv, Yichun Xu, Junsong Han, Hongjing Dou

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Abstract

In oxygen (O₂)-dependent photodynamic therapy (PDT), photosensitizers absorb light energy, which is then transferred to ambient O₂ and subsequently generates cytotoxic singlet oxygen (¹O₂). Therefore, the availability of O₂ and the utilization efficiency of generated ¹O₂ are two significant factors that influence the effectiveness of PDT. However, tumor microenvironments (TMEs) characterized by hypoxia and limited utilization efficiency of ¹O₂ resulting from its short half-life and short diffusion distance significantly restrict the applicability of PDT for hypoxic tumors. To address these challenges, numerous macromolecular nano-assemblies (MNAs) have been designed to relieve hypoxia, utilize hypoxia or enhance the utilization efficiency of ¹O₂. Herein, we provide a comprehensive review on recent advancements achieved with MNAs in enhancing the effectiveness of O₂-dependent PDT against hypoxic tumors.

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用于增强氧依赖性光动力疗法对缺氧性肿瘤的疗效的大分子纳米组合。

在依赖氧气（O2）的光动力疗法（PDT）中，光敏剂吸收光能，然后将光能转移到环境中的氧气，随后产生具有细胞毒性的单线态氧（1O2）。因此，O2 的可用性和生成的 1O2 的利用效率是影响 PDT 疗效的两个重要因素。然而，以缺氧为特征的肿瘤微环境（TMEs）以及1O2的短半衰期和短扩散距离导致的有限利用效率极大地限制了PDT对缺氧肿瘤的适用性。为了应对这些挑战，人们设计了许多大分子纳米组合（MNA）来缓解缺氧、利用缺氧或提高 1O2 的利用效率。在此，我们将全面综述最近在利用 MNAs 提高氧气依赖性 PDT 对缺氧肿瘤的疗效方面取得的进展。

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.