Sojin Song , Myeong Jin Jeon , Jong Uk Lee , Sang Jun Sim
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引用次数: 0
Abstract
DNA nanotechnology is driven by the precision and programmable properties of DNA, which serves as a reliable template to guide the self-assembly of various materials, such as metal nanoparticles and polymers. By integrating DNA nanotechnology into the synthesis of plasmonic nanomaterials, unprecedented precision in structural control is achieved, facilitating the fabrication of pre-designed nanostructures with modulated optical functionalities. In this comprehensive review, we explore various synthesis techniques (e.g., DNA linker-based assembly, DNA origami-based organization, and DNA-mediated growth), focusing on advanced DNA-assembled plasmonic nanoarchitecture (DAPNA). The article highlights the applications of DAPNA in localized surface plasmon resonance (LSPR) and surface-enhanced Raman scattering (SERS) based biosensors for diagnostic purposes. The review not only addresses the limitations and solutions in DAPNA manufacturing technology but also explores potential applications in biosensing, tissue engineering, gene editing, immunotherapy, and other emerging fields.
DNA 纳米技术由 DNA 的精确性和可编程特性驱动,它是指导金属纳米粒子和聚合物等各种材料自组装的可靠模板。通过将 DNA 纳米技术整合到质子纳米材料的合成中,可实现前所未有的精确结构控制,从而促进具有调制光学功能的预设计纳米结构的制造。在这篇综述中,我们探讨了各种合成技术(如基于 DNA 连接器的组装、基于 DNA 折纸的组织和 DNA 介导的生长),重点介绍了先进的 DNA 组装质子纳米结构(DAPNA)。文章重点介绍了 DAPNA 在基于局部表面等离子体共振(LSPR)和表面增强拉曼散射(SERS)的生物传感器中的应用。这篇综述不仅论述了 DAPNA 制造技术的局限性和解决方案,还探讨了其在生物传感、组织工程、基因编辑、免疫疗法和其他新兴领域的潜在应用。
期刊介绍:
TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.