Electrochemistry of flavin-based electron bifurcation: ‘Current’ past and ‘potential’ futures

IF 7.9 2区 化学 Q1 CHEMISTRY, PHYSICAL
Syed Muhammad Saad Imran , Seth A. Wiley , Carolyn E. Lubner
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引用次数: 0

Abstract

Flavin-based electron bifurcation (FBEB) was discovered as a significant process of microbial energy conservation less than two decades ago. Since then, several classes of enzymes engaging in FBEB have been identified, all of which utilize a flavin cofactor that accepts two electrons and then transfers one along an exergonic (high-potential) pathway and the other along an endergonic (low-potential) pathway. We describe the critical role of electrochemical techniques, especially protein-film voltammetry and spectroelectrochemistry, in determining the mechanism and energetic landscape of FBEB in a characteristic enzyme. A prospectus of future directions involving currently unutilized electrochemical techniques is discussed with regards to the salient open questions in the field of FBEB.

Abstract Image

Abstract Image

基于黄素的电子分叉电化学:"当前 "的过去和 "潜在 "的未来
不到二十年前,人们发现黄素电子分叉(FBEB)是微生物能量守恒的一个重要过程。从那时起,参与 FBEB 的几类酶已被确定,它们都利用黄素辅助因子接受两个电子,然后将其中一个电子沿着外能(高电位)途径转移,另一个电子沿着内能(低电位)途径转移。我们介绍了电化学技术,尤其是蛋白膜伏安法和光谱电化学技术在确定特征酶中 FBEB 的机制和能量分布方面的关键作用。针对 FBEB 领域的突出开放性问题,我们讨论了涉及目前尚未使用的电化学技术的未来发展方向。
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来源期刊
Current Opinion in Electrochemistry
Current Opinion in Electrochemistry Chemistry-Analytical Chemistry
CiteScore
14.00
自引率
5.90%
发文量
272
审稿时长
73 days
期刊介绍: The development of the Current Opinion journals stemmed from the acknowledgment of the growing challenge for specialists to stay abreast of the expanding volume of information within their field. In Current Opinion in Electrochemistry, they help the reader by providing in a systematic manner: 1.The views of experts on current advances in electrochemistry in a clear and readable form. 2.Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. In the realm of electrochemistry, the subject is divided into 12 themed sections, with each section undergoing an annual review cycle: • Bioelectrochemistry • Electrocatalysis • Electrochemical Materials and Engineering • Energy Storage: Batteries and Supercapacitors • Energy Transformation • Environmental Electrochemistry • Fundamental & Theoretical Electrochemistry • Innovative Methods in Electrochemistry • Organic & Molecular Electrochemistry • Physical & Nano-Electrochemistry • Sensors & Bio-sensors •
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