Experimental biological studies of novel tetradentate hydrazone Cu(II) complexes for potential applications in medicinal chemistry

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
C. Topkaya
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引用次数: 0

Abstract

A series of mononuclear Cu(II) complexes were synthesized using a potential tetradentate hydrazone ligand obtained from the reaction between phenylhydrazine groups and 2,5-thiophenedicarboxaldehyde. The structures of ligands and complexes were elucidated through various spectroscopic techniques, confirming their composition. All complexes were found to adopt four-coordinated geometries, indicating the formation of stable structures. Spectroscopic analysis revealed that the hydrazone ligand coordinated with the Cu(II) metal ions as a dibasic tetradentate ligand by utilizing the phenolic oxygen and azomethine nitrogen atoms. The binding affinity of the complexes with calf thymus DNA (CT-DNA) was investigated using absorption and viscosity measurements, demonstrating their interaction through the intercalation mode. The binding studies showed that the Cu(II) complexes exhibited varying degrees of binding affinity, with Cu(L4) demonstrating the highest affinity, followed by Cu(L1), Cu(L2), and Cu(L3). Moreover, the DNA fragmentation properties of the Cu(II) complexes were evaluated, suggesting their potential utilization in pharmaceutical applications. The obtained results highlight the significance of these novel complexes in the field of medicinal chemistry.
新型四价腙Cu(II)配合物在药物化学中的潜在应用的实验生物学研究
利用苯肼基团与 2,5-噻吩二甲醛反应得到的潜在四价腙配体,合成了一系列单核铜(II)配合物。配体和配合物的结构通过各种光谱技术得以阐明,并确认了它们的组成。发现所有配合物均采用四配位几何结构,表明形成了稳定的结构。光谱分析显示,腙配体利用酚氧原子和偶氮甲基氮原子与铜(II)金属离子配位为二元四配位体。利用吸收和粘度测量法研究了配合物与小牛胸腺 DNA(CT-DNA)的结合亲和力,证明它们是通过插层模式相互作用的。结合研究表明,Cu(II) 复合物表现出不同程度的结合亲和力,其中 Cu(L4) 表现出最高的亲和力,其次是 Cu(L1)、Cu(L2) 和 Cu(L3)。此外,还对 Cu(II) 复合物的 DNA 断裂特性进行了评估,这表明它们有可能被应用于制药领域。研究结果凸显了这些新型配合物在药物化学领域的重要意义。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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