Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as predictors of mortality in acute pulmonary embolism: A systematic review and meta-analysis

IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Pakistan Journal of Medical Sciences Pub Date : 2024-05-22 DOI:10.12669/pjms.40.6.8802

Shanshan Tang, Yanhua Hu

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引用次数: 0

Abstract

Objective: The purpose of this review was to examine the association between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and mortality rates in patients with acute pulmonary embolism (PE). Methods: PubMed Central, Scopus, Web of Science, and Embase were searched for studies reporting the association between NLR and PLR with mortality up to March 17th 2023. Adjusted ratios were sourced from studies and combined to generate pooled outcomes as odds ratio (OR) in a random-effects model. Risk of bias was assessed using the Newcastle Ottawa Scale. Results: Fifteen studies were included. Meta-analysis showed that NLR was a significant predictor of mortality in patients with PE (OR: 1.42 95% CI: 1.26, 1.61 I2=92%). Results were unchanged on sensitivity analysis and subgroup analysis based on study location, method of diagnosis, sample size, overall mortality rates, cut-offs, and follow-up. Pooled analysis failed to demonstrate PLR as a predictor of mortality in patients with PE (OR: 1.00 95% CI: 1.00, 1.01 I2=57%). Results were unchanged on sensitivity analysis and subgroup analysis based on study location, diagnosis of PE, overall mortality rates, and cut-off. Conclusion: Current evidence from retrospective studies shows that NLR can independently predict mortality in acute PE. Data on PLR was limited and failed to indicate an independent role in the prognosis of PE patients. Registration No. PROSPERO (CRD42023407573). doi: https://doi.org/10.12669/pjms.40.6.8802 How to cite this: Tang S, Hu Y. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as predictors of mortality in acute pulmonary embolism: A systematic review and meta-analysis. Pak J Med Sci. 2024;40(6):1274-1279. doi: https://doi.org/10.12669/pjms.40.6.8802 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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预测急性肺栓塞死亡率的中性粒细胞与淋巴细胞比率和血小板与淋巴细胞比率：系统回顾和荟萃分析

研究目的本综述旨在研究急性肺栓塞（PE）患者的中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）与死亡率之间的关系。研究方法检索了 PubMed Central、Scopus、Web of Science 和 Embase 中截至 2023 年 3 月 17 日报告 NLR 和 PLR 与死亡率关系的研究。从研究中获取调整比值，并在随机效应模型中以几率比（OR）的形式合并生成汇总结果。采用纽卡斯尔-渥太华量表评估偏倚风险。结果共纳入 15 项研究。Meta 分析表明，NLR 是预测 PE 患者死亡率的重要指标（OR：1.42 95% CI：1.26, 1.61 I2=92%）。根据研究地点、诊断方法、样本大小、总死亡率、临界值和随访情况进行的敏感性分析和亚组分析结果不变。汇总分析未能证明 PLR 可预测 PE 患者的死亡率（OR：1.00 95% CI：1.00, 1.01 I2=57%）。根据研究地点、PE 诊断、总死亡率和截止值进行的敏感性分析和亚组分析结果不变。结论目前来自回顾性研究的证据显示，NLR 可独立预测急性 PE 的死亡率。有关PLR的数据有限，且未能表明其在PE患者预后中的独立作用。注册号：PROSPERO (CRD42023407573)。doi: https://doi.org/10.12669/pjms.40.6.8802 如何引用：Tang S, Hu Y.预测急性肺栓塞死亡率的中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值：系统综述和荟萃分析。Pak J Med Sci. 2024;40(6):1274-1279. doi: https://doi.org/10.12669/pjms.40.6.8802 这是一篇开放获取的文章，根据知识共享署名许可协议 (http://creativecommons.org/licenses/by/3.0) 的条款发布，该协议允许在任何媒体上不受限制地使用、分发和复制，但须适当引用原作。

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来源期刊

Pakistan Journal of Medical Sciences 医学-医学：内科

CiteScore

4.10

自引率

9.10%

发文量

363

审稿时长

3-6 weeks

期刊介绍： It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad. Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.