Longitudinal hematological change in uncomplicated twin pregnancies: The white blood cell count decreases through pregnancy after the first trimester

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Masaki Sekiguchi , Jin Muromoto , Kohei Ogawa , Katsusuke Ozawa , Naoyuki Miyasaka , Haruhiko Sago
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Abstract

Objective

Longitudinal hematological changes throughout twin pregnancies have not been reported. This study aimed to reveal longitudinal changes in hematological indices in twin pregnancies.

Materials and methods

We conducted a retrospective chart review of hematological changes in uncomplicated twin pregnancies delivered at ≥37 weeks of gestation between 2010 and 2013 and randomly selected uncomplicated singletons during the same period. A complete blood count and hemogram were performed as blood examinations in the first trimester (9–13 weeks), late second trimester (22–27 weeks), mid-third trimester (33–35 weeks, only in twin pregnancies), and late third trimester (36–38 weeks). We evaluated inter-trimester differences in hematological indices and compared the values between twin and singleton pregnancies in each trimester.

Results

The final analysis group included 60 twin pregnancies and 63 singleton pregnancies. The white blood cell (WBC) count in twin pregnancies decreased throughout the pregnancy after the first trimester and became significantly lower than that in singletons in the late third trimester. The WBC count showed only a slight decrease in the third trimester in singleton pregnancies, whereas it showed a marked decrease throughout the pregnancy in twin pregnancies. The marked decrease in the total WBC count in twin pregnancies is mainly due to a decrease in neutrophils. The red blood cell count and hemoglobin and hematocrit values in twin pregnancies showed more marked decreases in the second trimester than in singletons. No decrease was observed after the second trimester of pregnancy. The platelet count decreased in the third trimester of twin pregnancies.

Conclusion

We clarified the longitudinal hematological changes in twin pregnancies that showed augmentation of or differed from those of singleton pregnancies. It should be specifically mentioned that the WBC count markedly decreased through pregnancy after the first trimester, which is a characteristic change in twin pregnancies.

无并发症双胎妊娠的纵向血液变化:妊娠头三个月后,白细胞计数在整个孕期下降
目的尚未有关于双胎妊娠血液学纵向变化的报道。材料和方法 我们对 2010 年至 2013 年期间妊娠≥37 周的无并发症双胎妊娠和同期随机选择的无并发症单胎妊娠的血液学变化进行了回顾性病历审查。在妊娠前三个月(9-13 周)、妊娠后三个月(22-27 周)、妊娠后三个月中期(33-35 周,仅适用于双胎妊娠)和妊娠后三个月后期(36-38 周)进行了全血细胞计数和血象检查。我们评估了各孕期血液指标的差异,并比较了双胎妊娠和单胎妊娠在各孕期的数值。双胎妊娠的白细胞(WBC)计数在妊娠头三个月后一直下降,在妊娠晚期的第三个月明显低于单胎妊娠。单胎妊娠的白细胞计数在妊娠三个月时仅有轻微下降,而双胎妊娠的白细胞计数在整个妊娠期间都有明显下降。双胎妊娠中白细胞总数的显著下降主要是由于中性粒细胞的减少。与单胎妊娠相比,双胎妊娠的红细胞计数、血红蛋白和血细胞比容值在妊娠后三个月的下降更为明显。在妊娠的第二个三个月后则没有观察到下降。结论我们明确了双胎妊娠的纵向血液学变化,这些变化与单胎妊娠的变化相比有所增强或不同。需要特别指出的是,白细胞计数在妊娠头三个月后明显下降,这是双胎妊娠的特征性变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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