Precise lymph node biopsy for endometrial cancer confined to the uterus: Analysis of 43 clinical cases

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Xiao-Long Shi , Shuo Chen , Guo-Dong Guo , Yun-Ling Yang , Kang-Mei Tong , Wen Cao , Lin-Lin Huang , Yan-Ru Zhang
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引用次数: 0

Abstract

Objective

To explore a precise association between tumor location and lymph node (LN) biopsy algorithm in uterine confined endometrial cancer (EC).

Materials and methods

Patients with EC treated in the Department of Obstetrics and Gynecology, South Branch of Fujian Provincial Hospital were included in this observational retrospective study. Based on the procedure of treatment, patients were separated to stage I (2015.07–2019.09) and stage II (2019.09–2021.9). In each stage, patients were separated to high and low-risk group by the predicted results. Patients in the high-risk group received systematic lymphadenectomy in stage I and sentinel lymph node (SLN) dissection in stage II. The efficiency of lymph node metastasis (LNM) detection rates was compared between stage I and stage II cases. Precise lymph node biopsy algorithm was also constructed based on the outcomes of stage II.

Results

Overall, 43 patients, 28 in stage I and 15 in stage II, were included in the study. No recurrence or death cases had been found within follow-up terms. Based on the difference in the detection efficiency of LNM (p > 0.05), there was no difference between two stages. Thus, systematic lymphadenectomy and SLN biopsy provided similar success rates. The location of tumor site was also important for deciding whether pelvic or para-aortic SLN should be sampled for LNM.

Conclusions

Precise SLN biopsy for EC confined to the uterus showed comparable LNM detection rate as systematic lymphadenectomy. EC location may be used to determine whether pelvic or para-aortic SLN sampling should be conducted for treatment.

对局限于子宫的子宫内膜癌进行精确淋巴结活检:43 例临床病例分析
摘要] 目的 探讨子宫局限性子宫内膜癌(EC)肿瘤位置与淋巴结活检算法之间的精确关联。根据治疗过程,将患者分为Ⅰ期(2015.07-2019.09)和Ⅱ期(2019.09-2021.9)。在每个阶段,根据预测结果将患者分为高风险组和低风险组。高风险组患者在I期接受系统淋巴结切除术,在II期接受前哨淋巴结(SLN)清扫术。比较了 I 期和 II 期病例的淋巴结转移(LNM)检出率。研究共纳入 43 例患者,其中 28 例为 I 期,15 例为 II 期。随访期间未发现复发或死亡病例。根据 LNM 检测效率的差异(P> 0.05),两期之间没有差异。因此,系统性淋巴腺切除术和 SLN 活检术的成功率相似。肿瘤部位的位置对于决定盆腔还是主动脉旁 SLN 取样检测 LNM 也很重要。EC的位置可用于确定应进行盆腔还是主动脉旁SLN取样治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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