Effects of protein glycation and protective mechanisms against glycative stress

IF 4 3区 医学 Q1 PHARMACOLOGY & PHARMACY
Jade A. Najjar, John W. Calvert
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引用次数: 0

Abstract

Glycation is a posttranslational modification of proteins that contributes to the vast array of biological information that can be conveyed via a singular proteome. Understanding the role of advanced glycation end-products (AGEs) in human health and pathophysiology can be difficult, as the physiological effects of AGEs have been associated with multiple biological processes and disease state development, including acute myocardial ischemia-reperfusion injury, heart failure, and atherosclerosis, as well as tumor cell migration. The critical role of the glyoxalase system in the detoxification of methylglyoxal and other AGEs has been well established. Recently, evidence has emerged that DJ-1 displays antiglycative activity and may contribute to another mechanism of protection against protein glycation outside of the glyoxalase system. Identification of potential substrates of DJ-1 and determination of the pathways in which DJ-1 operates, is needed to fully understand the role of this protein in modulating biological homeostasis and the development of disease.

蛋白质糖化的影响和糖化应激的保护机制
糖化是蛋白质的一种翻译后修饰,可通过单个蛋白质组传递大量生物信息。了解高级糖化终产物(AGEs)在人类健康和病理生理学中的作用可能很困难,因为 AGEs 的生理效应与多种生物过程和疾病状态的发展有关,包括急性心肌缺血再灌注损伤、心力衰竭、动脉粥样硬化以及肿瘤细胞迁移。乙二醛酶系统在甲基乙二醛和其他 AGEs 的解毒过程中的关键作用已得到公认。最近有证据表明,DJ-1 具有抗糖化活性,可能是乙二醛酶系统之外另一种防止蛋白质糖化的机制。要全面了解 DJ-1 蛋白在调节生物稳态和疾病发展中的作用,就需要鉴定 DJ-1 的潜在底物并确定 DJ-1 的作用途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.80
自引率
2.50%
发文量
131
审稿时长
4-8 weeks
期刊介绍: Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.
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