Circulating microaggregates as biomarkers for the Post‐COVID syndrome

IF 1.1 Q4 INFECTIOUS DISEASES
IDCases Pub Date : 2024-01-01 DOI:10.1016/j.idcr.2024.e02000
M. Hermann , C. Lisch , R. Gerth , G. Wick , D. Fries , N. Wick
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引用次数: 0

Abstract

CoVID-19 can develop into Post-COVID syndrome of potentially high morbidity, with procoagulation and reactivation of dormant viral infections being hypothesized pathophysiological mechanisms. We report on a patient suffering from fatigue, post exertional malaise, pain and neurological symptoms as a consequence of the second CoVID infection. Using live confocal microscopy on native whole blood samples we detected microaggregates of thrombocytes, leukocytes and plasma proteins in peripheral blood. In addition, there was specific cellular immunological reactivity to EBV. Upon anticoagulatory and virustatic pharmacological therapy we observed dissolution of microaggregates and significant stable clinical remission. We suggest to consider circulating microaggregates as a morphological indicator of chronic post-COVID syndrome.

作为后 COVID 综合征生物标志物的循环微聚集体
CoVID-19 可发展为具有潜在高发病率的后 CoVID 综合征,其假设的病理生理机制是促凝血和休眠病毒感染再活化。我们报告了一名因第二次感染 CoVID 而出现疲劳、劳累后不适、疼痛和神经症状的患者。通过对原生全血样本进行活体共聚焦显微镜观察,我们在外周血中检测到血小板、白细胞和血浆蛋白的微聚集。此外,EB 病毒还具有特异性细胞免疫反应。经过抗凝和抗病毒药物治疗后,我们观察到微聚集体溶解,临床症状明显稳定缓解。我们建议将循环微聚集体视为慢性后 COVID 综合征的形态学指标。
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来源期刊
IDCases
IDCases INFECTIOUS DISEASES-
CiteScore
2.60
自引率
6.70%
发文量
300
审稿时长
10 weeks
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