Repurposing of biologics and biopharmaceuticals.

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Juveriya Israr, Shabroz Alam, Vijai Singh, Ajay Kumar
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引用次数: 0

Abstract

The field of drug repurposing is gaining attention as a way to introduce pharmaceutical agents with established safety profiles to new patient populations. This approach involves finding new applications for existing drugs through observations or deliberate efforts to understand their mechanisms of action. Recent advancements in bioinformatics and pharmacology, along with the availability of extensive data repositories and analytical techniques, have fueled the demand for novel methodologies in pharmaceutical research and development. To facilitate systematic drug repurposing, various computational methodologies have emerged, combining experimental techniques and in silico approaches. These methods have revolutionized the field of drug discovery by enabling the efficient repurposing of screens. However, establishing an ideal drug repurposing pipeline requires the integration of molecular data accessibility, analytical proficiency, experimental design expertise, and a comprehensive understanding of clinical development processes. This chapter explores the key methodologies used in systematic drug repurposing and discusses the stakeholders involved in this field. It emphasizes the importance of strategic alliances to enhance the success of repurposing existing compounds for new indications. Additionally, the chapter highlights the current benefits, considerations, and challenges faced in the repurposing process, which is pursued by both biotechnology and pharmaceutical companies. Overall, drug repurposing holds great promise in expanding the use of existing drugs and bringing them to new patient populations. With the advancements in computational methodologies and the collaboration of various stakeholders, this approach has the potential to accelerate drug development and improve patient outcomes.

生物制品和生物制药的再利用。
药物再利用领域正日益受到关注,因为它是一种将具有既定安全性的药物引入新患者群体的方法。这种方法是通过观察或有意识地了解现有药物的作用机制,为其寻找新的应用领域。生物信息学和药理学的最新进展,以及大量数据存储库和分析技术的可用性,推动了制药研发领域对新方法的需求。为了促进系统性的药物再利用,出现了各种结合实验技术和硅学方法的计算方法。这些方法通过实现高效的再利用筛选,彻底改变了药物发现领域。然而,要建立一个理想的药物再利用管道,需要将分子数据的可获取性、分析能力、实验设计专长以及对临床开发流程的全面了解融为一体。本章探讨了系统性药物再利用中使用的关键方法,并讨论了这一领域的利益相关者。它强调了战略联盟对于提高现有化合物在新适应症中再利用的成功率的重要性。此外,本章还重点介绍了生物技术公司和制药公司在药物再利用过程中目前面临的益处、注意事项和挑战。总之,药物再利用在扩大现有药物的使用范围并为新的患者群体带来福音方面大有可为。随着计算方法的进步和各利益相关方的合作,这种方法有可能加快药物开发并改善患者的治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.00
自引率
0.00%
发文量
110
审稿时长
4-8 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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