Insights into incipient oral squamous cell carcinoma: a comprehensive south-american study.

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Medicina Oral Patologia Oral Y Cirugia Bucal Pub Date : 2024-07-01 DOI:10.4317/medoral.26551

C Saldivia-Siracusa, A-L Araújo, L-P Arboleda, T Abrantes, M-B Pinto, N Mendonça, K Cordero-Torres, G Gilligan, E Piemonte, R Panico, F De-Abreu-Álves, M Villaroel-Dorrego

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Abstract

Background: To describe demographic and clinicopathological aspects of a South-American cohort of incipient oral squamous cell carcinoma patients.

Material and methods: A cross-sectional, observational study was performed to assess demographic and clinicopathological characteristics of incipient oral squamous cell carcinoma patients from 6 South-American institutions.

Results: One hundred and seven patients within the histopathological spectrum of incipient oral squamous cell carcinoma (in-situ and microinvasive) were included. Fifty-eight (54.2%) patients were men with a mean age of 60.69 years. Forty-nine (45.8%) and thirty-nine (36.5%) patients had history of tobacco and alcohol use, respectively. Clinically, most of the lesions were plaques (82.2%), ≥ 2 cm in extension (72%), affecting the lateral border of the tongue (55.1%), and soft palate (12.1%) with a mixed (white and red) appearance. Eighty-two (76.7%) lesions were predominantly white and 25 (23.3%) predominantly red.

Conclusions: To the best of our knowledge, this is the largest cohort of incipient oral squamous cell carcinoma patients, which raises awareness of clinicians' inspection acuteness by demonstrating the most frequent clinical aspects of this disease, potentially improving oral cancer secondary prevention strategies.

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对萌芽期口腔鳞状细胞癌的见解：一项综合性南美研究。

背景：描述南美口腔鳞状细胞癌初期患者的人口统计学和临床病理学方面的情况：描述南美初发口腔鳞状细胞癌患者的人口统计学和临床病理学特征：进行了一项横断面观察研究，以评估来自南美6家机构的初发口腔鳞状细胞癌患者的人口统计学和临床病理学特征：结果：研究共纳入了 177 名属于口腔鳞状细胞癌（原位癌和微浸润癌）萌芽期组织病理学类型的患者。58名（54.2%）患者为男性，平均年龄为60.69岁。49名（45.8%）和39名（36.5%）患者分别有吸烟和饮酒史。临床上，大多数病变为斑块（82.2%），扩展范围≥2厘米（72%），累及舌外侧缘（55.1%）和软腭（12.1%），呈混合型（白色和红色）。82个病灶（76.7%）以白色为主，25个病灶（23.3%）以红色为主：据我们所知，这是规模最大的口腔鳞状细胞癌初期患者队列，通过展示该疾病最常见的临床表现，提高了临床医生的检查意识，从而有可能改进口腔癌二级预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicina Oral Patologia Oral Y Cirugia Bucal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology