Helicobacter pylori infection found during upper endoscopy performed for the diagnosis of celiac, inflammatory bowel diseases, and eosinophilic esophagitis: A multicenter pediatric European study

IF 4.3 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Helicobacter Pub Date : 2024-05-24 DOI:10.1111/hel.13092

Kallirroi Kotilea, Claudio Romano, Erasmo Miele, Angelika Kindermann, Yael Dolstra, Zrinjka Misak, Vaidotas Urbonas, Josef Sykora, Pedro Urruzuno, Alexander Krauthammer, Maria Rogalidou, Konstantina Dimakou, Tsili Zangen, Eleftheria Roma, Aglaia Zellos, María Luz Cilleruelo, Meline M'Rini, Patrick Bontems, Yasin Sahin, Marta Tavares, Tatevik Shahinyan, Biljana Vuletic, Nicolas Kalach, Michal Kori, the ESPGHAN H. pylori special interest group

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引用次数: 0

Abstract

Background

Helicobacter pylori may be found during upper gastrointestinal endoscopy (UGE) performed to diagnose celiac disease (CeD), inflammatory bowel disease (IBD), and eosinophilic esophagitis (EoE). We aimed to describe the frequency of H. pylori in children undergoing UGE for CeD, IBD, and EoE and the number of children receiving eradication treatment.

Materials and Methods

A retrospective multicenter study from 14 countries included pediatric patients diagnosed with CeD, IBD, and EoE between January 2019 and December 2021. Data collected: age, gender, hematologic parameters, endoscopic, histologic, and H. pylori culture results, and information on eradication treatment.

Results

H. pylori was identified in 349/3890 (9%) children [167 (48%) male, median 12 years (interquartile range 8.1–14.6)]. H. pylori was present in 10% (173/1733) CeD, 8.5% (110/1292) IBD and 7.6% (66/865) EoE patients (p = NS). The prevalence differed significantly between Europe (Eastern 5.2% (28/536), Southern 3.8% (78/2032), Western 5.6% (28/513)) and the Middle East 26.6% (215/809) [odds ratio (OR) 7.96 95% confidence interval (CI) (6.31–10.1) p < 0.0001]. Eradication treatment was prescribed in 131/349 (37.5%) patients, 34.6% CeD, 35.8% IBD, and 56.1% EoE. Predictors for recommending treatment included erosions/ulcers [OR 6.45 95% CI 3.62–11.47, p < 0.0001] and nodular gastritis [OR 2.25 95% CI 1.33–3.81, p 0.003]. Treatment rates were higher in centers with a low H. pylori prevalence (<20%) [OR 3.36 95% CI 1.47–7.66 p 0.004].

Conclusions

Identifying H. pylori incidentally during UGE performed for the most common gastrointestinal diseases varies significantly among regions but not among diseases. The indications for recommending treatment are not well defined, and less than 40% of children received treatment.

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为诊断糜烂性胃炎、炎症性肠病和嗜酸性食管炎而进行上内镜检查时发现的幽门螺杆菌感染：一项欧洲多中心儿科研究。

背景：为诊断糜烂性胃炎（CeD）、炎症性肠病（IBD）和嗜酸性食管炎（EoE）而进行的上消化道内窥镜检查（UGE）可能会发现幽门螺杆菌。我们旨在描述因糜烂性胃炎、炎症性肠病和嗜酸性食管炎而接受 UGE 检查的儿童中幽门螺杆菌的感染频率以及接受根除治疗的儿童人数：一项来自14个国家的回顾性多中心研究纳入了2019年1月至2021年12月期间被诊断为CeD、IBD和EoE的儿童患者，收集的数据包括：年龄、性别、血液学参数、内镜、组织学和幽门螺杆菌培养结果以及根除治疗信息：结果：349/3890（9%）名儿童中发现了幽门螺杆菌[167（48%）名男性，中位数为 12 岁（四分位数间距为 8.1-14.6）]。10%（173/1733）CeD、8.5%（110/1292）IBD 和 7.6%（66/865）EoE 患者体内存在幽门螺杆菌（p = NS）。欧洲（东部 5.2% (28/536)、南部 3.8% (78/2032)、西部 5.6% (28/513)）和中东 26.6% (215/809)之间的患病率存在显著差异[比值比 (OR) 7.96 95% 置信区间 (CI) (6.31-10.1) p 结论：在对最常见的胃肠道疾病进行胃镜检查时偶然发现幽门螺杆菌，不同地区之间存在显著差异，但不同疾病之间的差异不大。建议治疗的适应症没有明确界定，只有不到 40% 的儿童接受了治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Helicobacter 医学-微生物学

CiteScore

8.40

自引率

9.10%

发文量

审稿时长

2 months

期刊介绍： Helicobacter is edited by Professor David Y Graham. The editorial and peer review process is an independent process. Whenever there is a conflict of interest, the editor and editorial board will declare their interests and affiliations. Helicobacter recognises the critical role that has been established for Helicobacter pylori in peptic ulcer, gastric adenocarcinoma, and primary gastric lymphoma. As new helicobacter species are now regularly being discovered, Helicobacter covers the entire range of helicobacter research, increasing communication among the fields of gastroenterology; microbiology; vaccine development; laboratory animal science.