The explosive discovery of TNT in early mouse embryos

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-05-24 DOI:10.1038/s41594-024-01304-8

Chad S. Driscoll, Jaehwan Kim, Jason G. Knott

引用次数: 0

Abstract

The molecular mechanisms that regulate the transition from totipotency into divergent cellular states are unclear. Two new studies show that the transcription factors TFAP2C, NR5A2 and TEAD4 (TNT) support the formation of a transient bipotent state by activating early pluripotency and trophectoderm genes and modulating HIPPO signaling.

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小鼠早期胚胎中 TNT 的爆炸性发现

目前尚不清楚调控从全能性过渡到分化细胞状态的分子机制。两项新研究表明，转录因子TFAP2C、NR5A2和TEAD4（TNT）通过激活早期全能性基因和滋养层基因以及调节HIPPO信号转导，支持形成短暂的双能状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.