Tumor budding is a prognostic marker for overall survival and not for lymph node metastasis in Oral Squamous Cell Carcinoma – Systematic Review Update and Meta-Analysis

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2024-05-23 DOI:10.1016/j.jobcr.2024.04.013

Gouri S. Panchannavar , Punnya V. Angadi

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引用次数: 0

Abstract

Objective

Tumor budding (TB) has shown promising results as a prognostic marker in several cancers such as colorectal carcinoma, breast carcinoma etc. It has been co-related to aggressiveness of the tumor and can also predict the metastasis to the lymph nodes. This systematic review evaluates the prognostic potential of TB in predicting lymph node metastasis (LNM) in OSCC.

Data sources

Systematic search was carried out in the electronic data-bases i.e. PubMed, Cochrane and Google scholar for original studies related to TB in OSCC. The assessment of risk bias was done using QUIPS tool. Meta-analysis was done using STATA software.

Results

A total of 25 articles were included. A significant association was noted for overall survival and prognosis but not for TB LNM in OSCC. Meta-analysis revealed a pooled estimate i.e odds ratio of 2.10 (CI - 0.00 - 4.20) for TB and LNM while for overall survival, it was 2.29 (CI-1.81–2.76).

Conclusion

Tumor budding though is strongly associated with LNM in OSCC did not show significant relationship in this systematic review but demonstrated a higher correlation with overall survival. It highlights that TB is an important parameter for prognosis of oral cancer but its potential in prediction of LNM needs further validation.

Abstract Image

查看原文本刊更多论文

肿瘤萌芽是口腔鳞状细胞癌总生存率的预后指标，而不是淋巴结转移的预后指标 - 系统综述更新和元分析

肿瘤萌芽（TB）作为结肠直肠癌、乳腺癌等多种癌症的预后标志物已显示出良好的效果。它与肿瘤的侵袭性密切相关，还能预测淋巴结转移。本系统综述评估了TB在预测OSCC淋巴结转移（LNM）方面的预后潜力。数据来源在PubMed、Cochrane和Google scholar等电子数据库中对OSCC中TB的相关原始研究进行了系统检索。使用 QUIPS 工具进行风险偏倚评估。结果共纳入 25 篇文章。研究发现，OSCC患者的总生存率和预后与结核病LNM无明显关系。Meta 分析显示，TB 和 LNM 的集合估计值即几率比为 2.10（CI - 0.00 - 4.20），而总生存率为 2.29（CI-1.81-2.76）。这表明肿瘤萌芽是口腔癌预后的一个重要参数，但其预测 LNM 的潜力还需要进一步验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.