Pharmaceutical therapies targeting autophagy for the treatment of age-related macular degeneration

IF 4 3区 医学 Q1 PHARMACOLOGY & PHARMACY
Kirstan A. Vessey , Andrew I. Jobling , Ursula Greferath , Erica L. Fletcher
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引用次数: 0

Abstract

Age-related macular degeneration (AMD) is a major cause of irreversible vision loss in the elderly. Although new therapies have recently emerged, there are currently no ways of preventing the development of the disease. Changes in intracellular recycling processes. Changes in intracellular recycling processes, called autophagy, lead to debris accumulation and cellular dysfunction in AMD models and AMD patients. Drugs that enhance autophagy hold promise as therapies for slowing AMD progression in preclinical models; however, more studies in humans are required. While a definitive cure for AMD will likely hinge on a personalized medicine approach, treatments that enhance autophagy hold promise for slowing vision loss.

治疗老年性黄斑变性的自噬药物疗法
老年黄斑变性(AMD)是导致老年人视力不可逆转丧失的主要原因。虽然最近出现了一些新疗法,但目前还没有预防该病发展的方法。细胞内循环过程的变化。细胞内循环过程(自噬)的变化会导致AMD模型和AMD患者体内碎片堆积和细胞功能障碍。在临床前模型中,增强自噬功能的药物有望成为减缓老年性黄斑变性进展的疗法;然而,还需要在人体中进行更多的研究。虽然彻底治愈老年性黄斑变性可能取决于个性化医疗方法,但增强自噬功能的疗法有望减缓视力丧失。
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来源期刊
CiteScore
8.80
自引率
2.50%
发文量
131
审稿时长
4-8 weeks
期刊介绍: Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.
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