Can peri-surgical electroacupuncture relieve immunity suppression? A pilot study in dogs

IF 2.3 2区农林科学 Q1 VETERINARY SCIENCES

Veterinary journal Pub Date : 2024-06-01 DOI:10.1016/j.tvjl.2024.106140

V. Rabbogliatti, F.A. Brioschi, A. Pecile, V. Bronzo, V. Martini, P. Dall’Ara, G. Ravasio, D. Groppetti

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Abstract

General anesthesia and surgical stress can suppress the immunological response by acting both directly on the immune system and indirectly on the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Disturbance of the immune system during the perioperative period can lead to complications such as wound-healing disorders and infections up to sepsis. Effectiveness of acupuncture in regulating the immune function by increasing leukocyte numbers and inhibiting inflammatory response has been proven. This study aimed to explore the impact of electroacupuncture (EAP) on the dynamic balance of the immune system and immune cell populations in dogs undergoing surgery. Twelve healthy bitches scheduled for elective ovariectomy were divided into two groups according to whether (EAP, n=6) or not (CTR, n=6) a peri-operative electroacupuncture treatment was performed. Levels of leukocytes (neutrophils, monocytes, T- and B-cells) and immunoglobulins M (IgM) and A (IgA) were measured in blood samples collected before (T0), 1 h (T1) and 2.5 h (T2) after anesthesia induction. Leukocytes count decreased from T0 to T1 in both groups and restored within 1.5 h in EAP group whereas remained significantly lower in CTR group (P<0.02). In particular, neutrophils and monocytes increased in dogs receiving EAP (P<0.01) while T-cells decreased in CTR group (P<0.04) at T2. B-cells and cytotoxic T-cells decreased in EAP dogs (P<0.04) at T2. No differences in helper T-cells, IgM and IgA levels were recorded between groups and over time. Our results suggest a modulatory effect of EAP on the immune system which is early expressed on neutrophils, monocytes and T-cells.

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围手术期电针能缓解免疫抑制吗？一项在狗身上进行的试验性研究。

全身麻醉和手术压力可直接作用于免疫系统，并间接作用于下丘脑-垂体-肾上腺轴和交感神经系统，从而抑制免疫反应。围手术期免疫系统紊乱可导致伤口愈合障碍、感染甚至败血症等并发症。针灸通过增加白细胞数量和抑制炎症反应来调节免疫功能的有效性已得到证实。本研究旨在探讨电针对手术犬免疫系统和免疫细胞群动态平衡的影响。研究人员将 12 只计划进行卵巢切除术的健康母犬按照是否进行围手术期电针治疗（EAP，6 只）（CTR，6 只）分为两组。在麻醉诱导前（T0）、麻醉诱导后 1 小时（T1）和 2.5 小时（T2）采集的血液样本中测量了白细胞（中性粒细胞、单核细胞、T 细胞和 B 细胞）以及免疫球蛋白 M（IgM）和 A（IgA）的水平。两组的白细胞计数从 T0 到 T1 均有所下降，EAP 组在 1.5 小时内恢复，而 CTR 组仍显著较低（P＜0.05）。

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来源期刊

Veterinary journal 农林科学-兽医学

CiteScore

4.10

自引率

4.50%

发文量

审稿时长

40 days

期刊介绍： The Veterinary Journal (established 1875) publishes worldwide contributions on all aspects of veterinary science and its related subjects. It provides regular book reviews and a short communications section. The journal regularly commissions topical reviews and commentaries on features of major importance. Research areas include infectious diseases, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology and oncology.