Sébastien Matlosz, Sigríður R. Franzdóttir, Arnar Pálsson, Zophonías O. Jónsson
{"title":"DNA methylation reprogramming in teleosts","authors":"Sébastien Matlosz, Sigríður R. Franzdóttir, Arnar Pálsson, Zophonías O. Jónsson","doi":"10.1111/ede.12486","DOIUrl":null,"url":null,"abstract":"<p>Early embryonic development is crucially important but also remarkably diverse among animal taxa. Axis formation and cell lineage specification occur due to both spatial and temporal control of gene expression. This complex system involves various signaling pathways and developmental genes such as transcription factors as well as other molecular interactants that maintain cellular states, including several types of epigenetic marks. 5mC DNA methylation, the chemical modification of cytosines in eukaryotes, represents one such mark. By influencing the compaction of chromatin (a high-order DNA structure), DNA methylation can either repress or induce transcriptional activity. Mammals exhibit a reprogramming of DNA methylation from the parental genomes in the zygote following fertilization, and later in primordial germ cells (PGCs). Whether these periods of methylation reprogramming are evolutionarily conserved, or an innovation in mammals, is an emerging question. Looking into these processes in other vertebrate lineages is thus important, and teleost fish, with their extensive species richness, phenotypic diversity, and multiple rounds of whole genome duplication, provide the perfect research playground for answering such a question. This review aims to present a concise state of the art of DNA methylation reprogramming in early development in fish by summarizing findings from different research groups investigating methylation reprogramming patterns in teleosts, while keeping in mind the ramifications of the methodology used, then comparing those patterns to reprogramming patterns in mammals.</p>","PeriodicalId":12083,"journal":{"name":"Evolution & Development","volume":"26 5","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Evolution & Development","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ede.12486","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Early embryonic development is crucially important but also remarkably diverse among animal taxa. Axis formation and cell lineage specification occur due to both spatial and temporal control of gene expression. This complex system involves various signaling pathways and developmental genes such as transcription factors as well as other molecular interactants that maintain cellular states, including several types of epigenetic marks. 5mC DNA methylation, the chemical modification of cytosines in eukaryotes, represents one such mark. By influencing the compaction of chromatin (a high-order DNA structure), DNA methylation can either repress or induce transcriptional activity. Mammals exhibit a reprogramming of DNA methylation from the parental genomes in the zygote following fertilization, and later in primordial germ cells (PGCs). Whether these periods of methylation reprogramming are evolutionarily conserved, or an innovation in mammals, is an emerging question. Looking into these processes in other vertebrate lineages is thus important, and teleost fish, with their extensive species richness, phenotypic diversity, and multiple rounds of whole genome duplication, provide the perfect research playground for answering such a question. This review aims to present a concise state of the art of DNA methylation reprogramming in early development in fish by summarizing findings from different research groups investigating methylation reprogramming patterns in teleosts, while keeping in mind the ramifications of the methodology used, then comparing those patterns to reprogramming patterns in mammals.
早期胚胎发育至关重要,但在动物分类群中也存在着显著的差异。轴的形成和细胞系的分化是通过基因表达的空间和时间控制实现的。这个复杂的系统涉及各种信号通路和发育基因(如转录因子),以及其他维持细胞状态的分子相互作用物,包括几种类型的表观遗传标记。5mC DNA 甲基化是真核生物中胞嘧啶的化学修饰,它就是其中一种标记。通过影响染色质(一种高阶 DNA 结构)的压实,DNA 甲基化可以抑制或诱导转录活动。哺乳动物在受精后的子代以及随后的原始生殖细胞(PGCs)中,DNA甲基化会对亲代基因组进行重编程。这些甲基化重编程时期是哺乳动物的进化保守,还是哺乳动物的创新,这是一个新出现的问题。因此,研究其他脊椎动物的这些过程非常重要,而远洋鱼类物种丰富、表型多样、全基因组多轮复制,为回答这一问题提供了完美的研究平台。本综述旨在通过总结不同研究小组对远洋鱼类甲基化重编程模式的研究结果,简要介绍DNA甲基化重编程在鱼类早期发育中的应用现状,同时考虑到所用方法的影响,然后将这些模式与哺乳动物的重编程模式进行比较。
期刊介绍:
Evolution & Development serves as a voice for the rapidly growing research community at the interface of evolutionary and developmental biology. The exciting re-integration of these two fields, after almost a century''s separation, holds much promise as the focus of a broader synthesis of biological thought. Evolution & Development publishes works that address the evolution/development interface from a diversity of angles. The journal welcomes papers from paleontologists, population biologists, developmental biologists, and molecular biologists, but also encourages submissions from professionals in other fields where relevant research is being carried out, from mathematics to the history and philosophy of science.