eIf3a mediates malignant biological behaviors in colorectal cancer through the PI3K/AKT signaling pathway.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-12-31 Epub Date: 2024-05-23 DOI:10.1080/15384047.2024.2355703

Chao Huo, Disheng Wu, Xiaodan Li, Yan Zhang, Baoguang Hu, Taoming Zhang, Jianwei Ren, Tianbao Wang, Yi Liu

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Abstract

Colorectal cancer (CRC) is among the most common gastrointestinal malignancies worldwide. eIF3a is highly expressed in a variety of cancer types, yet its role in CRC remains unclear. We introduced ectopic eIF3a expression in CRC cells to investigate its relevance to various malignant behaviors. Further, we silenced eIF3a to explore its effect on tumor growth in a nude mouse tumor xenograft model. Finally, the molecular mechanisms through which eIF3a regulates malignancy in CRC cells were explored through bioinformatics analysis combined with the use of a specific PI3K inhibitor (LY294002). eIF3a was highly expressed in the peripheral blood and cancer tissue of CRC patients. Malignancy and tumor growth were significantly inhibited by silencing eIF3a, while overexpression promoted malignant behaviors, with a positive correlation between PI3K/AKT activation and eIF3a expression. Taken together, eIF3a plays an oncogenic role in CRC by regulating PI3K/AKT signaling and is a potential biomarker for CRC diagnosis and prognostic monitoring.

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eIf3a 通过 PI3K/AKT 信号通路介导结直肠癌的恶性生物学行为。

大肠癌（CRC）是全球最常见的胃肠道恶性肿瘤之一。eIF3a在多种癌症类型中高度表达，但它在CRC中的作用仍不清楚。我们在 CRC 细胞中引入了 eIF3a 的异位表达，以研究它与各种恶性行为的相关性。此外，我们还在裸鼠肿瘤异种移植模型中沉默了 eIF3a，以探讨其对肿瘤生长的影响。最后，我们通过生物信息学分析，结合使用特异性 PI3K 抑制剂（LY294002），探讨了 eIF3a 调节 CRC 细胞恶性程度的分子机制。沉默eIF3a能显著抑制恶性肿瘤的发生和生长，而过表达则会促进恶性行为，PI3K/AKT的激活与eIF3a的表达呈正相关。综上所述，eIF3a通过调控PI3K/AKT信号在CRC中发挥致癌作用，是CRC诊断和预后监测的潜在生物标志物。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.