Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Journal of Natural Medicines Pub Date : 2024-05-24 DOI:10.1007/s11418-024-01814-1

Naohiro Oshima, Kosuke Kusamori, Ryo Takasaki, Moe Takeda, Yuri Katsurada, Takumi Nose, Kazuki Okoshi, Makiya Nishikawa, Noriyasu Hada

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Abstract

Scuellaria Root (SR, root of Scutellaria baicalensis), which has potent anti-inflammatory effects, is a component of useful Kampo formulae. Albeit a low frequency, SR induces serious interstitial pneumonia and liver dysfunction. In this study, to control the adverse effects of SR, we investigated the causal constituent responsible for its hepatocytotoxicity and aimed to develop a method to control it. As a result, we revealed that the hepatocytotoxicity of SR was correlated with its baicalin content, a major constituent in SR. It was confirmed by preparing a baicalin-free SR extract, which exhibited reduced hepatocytotoxicity. The addition of baicalin to the baicalin-free SR extract restored the hepatocytotoxicity, indicating that the hepatocytotoxicity of SR is dependent on its baicalin content. Thus, SR extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content.

Graphical abstract

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可通过调节黄芩苷的含量来控制黄芩根提取物诱导的肝细胞毒性。

黄芩根（SR，Scutellaria baicalensis 的根）具有强效消炎作用，是有用的康普配方中的一种成分。尽管使用频率较低，但黄芩根会诱发严重的间质性肺炎和肝功能障碍。在本研究中，为了控制 SR 的不良影响，我们调查了导致其肝细胞毒性的成因，并旨在开发一种控制方法。结果发现，SR 的肝细胞毒性与黄芩苷的含量有关，黄芩苷是 SR 的主要成分。通过制备不含黄芩苷的 SR 提取物证实了这一点，该提取物的肝细胞毒性有所降低。在不含黄芩苷的 SR 提取物中添加黄芩苷后，肝细胞毒性得以恢复，这表明 SR 的肝细胞毒性取决于其黄芩苷含量。因此，SR 提取物诱导的肝细胞毒性可通过调节其黄芩苷含量来控制。

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.