Cognitive performance and mortality among patients receiving autologous hematopoietic stem cell transplant.

IF 1.5 4区医学 Q4 PSYCHOLOGY, SOCIAL

Journal of Psychosocial Oncology Pub Date : 2024-01-01 Epub Date: 2024-05-22 DOI:10.1080/07347332.2024.2342843

Ellen Johnson, Sung Won Choi, John Stratton, Alison Sylvia, Flora Hoodin, Kristen Votruba

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引用次数: 0

Abstract

Objectives: Patients undergoing autologous hematopoietic stem cell transplant (HCT) are at risk for death and remain understudied relative to those undergoing allogeneic HCT. Cognitive functioning may be a useful indicator of mortality risk. We examined cognition among patients who underwent autologous HCT and its relationship to mortality.

Methods: Participants (N = 51; 11 patients deceased) completed tasks of processing speed, working memory, executive-mediated learning, and visual recall using the computerized CogState battery prior to HCT, 30 days post-autologous HCT, and 100 days post-autologous HCT.

Results: Slower processing speed (HR = 3.00) and more errors on an executive-mediated visual learning task (HR = 2.78) prior to HCT were associated with an increased risk of death following HCT. Our sample size limited longitudinal analyses of whether cognitive change predicted survival, however descriptive cognitive data of the deceased versus living patient's performances over time suggested different patterns of performance across groups.

Conclusions: Pre-HCT cognition may have utility as an indicator of mortality risk following autologous HCT. More research is needed to examine whether cognitive changes after HCT could also predict mortality.

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自体造血干细胞移植患者的认知能力和死亡率。

目的：接受自体造血干细胞移植（HCT）的患者面临死亡风险，但相对于接受异体造血干细胞移植的患者而言，相关研究仍然不足。认知功能可能是死亡风险的一个有用指标。我们研究了接受自体 HCT 患者的认知能力及其与死亡率的关系：参与者（N = 51；11 名患者死亡）在接受 HCT 前、接受自体 HCT 后 30 天和接受自体 HCT 后 100 天使用计算机化 CogState 电池完成处理速度、工作记忆、执行介导的学习和视觉记忆任务：结果：自体移植前处理速度较慢（HR = 3.00）、执行介导的视觉学习任务错误较多（HR = 2.78）与自体移植后死亡风险增加有关。我们的样本量限制了对认知变化是否能预测存活率的纵向分析，但死亡患者与存活患者在一段时间内的认知表现的描述性数据表明，不同组别的表现模式各不相同：结论：自体造血干细胞移植前的认知能力可作为自体造血干细胞移植后死亡风险的指标。结论：自体造血干细胞移植前的认知能力可能可作为自体造血干细胞移植后死亡风险的指标，但还需要更多的研究来探讨造血干细胞移植后的认知能力变化是否也能预测死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Psychosocial Oncology PSYCHOLOGY, SOCIAL-

CiteScore

4.20

自引率

0.00%

发文量

期刊介绍： Here is your single source of integrated information on providing the best psychosocial care possible from the knowledge available from many disciplines.The Journal of Psychosocial Oncology is an essential source for up-to-date clinical and research material geared toward health professionals who provide psychosocial services to cancer patients, their families, and their caregivers. The journal—the first interdisciplinary resource of its kind—is in its third decade of examining exploratory and hypothesis testing and presenting program evaluation research on critical areas, including: the stigma of cancer; employment and personal problems facing cancer patients; patient education.