The impact of chronic electronic cigarette use on endothelial dysfunction measured by flow-mediated vasodilation: A systematic review and meta-analysis.

IF 2.2 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Tobacco Induced Diseases Pub Date : 2024-05-22 eCollection Date: 2024-01-01 DOI:10.18332/tid/186932

Jieun Lee, Zhiqi Yao, Ellen Boakye, Michael J Blaha

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引用次数: 0

Abstract

Introduction: Despite electronic cigarettes (e-cigarettes) being marketed as a safer alternative to combustible cigarettes, the effects of chronic e-cigarette use on vascular health remain uncertain. Our meta-analysis aimed to assess the health implications of chronic exclusive e-cigarette use on endothelial dysfunction, as measured by flow-mediated vasodilation (FMD).

Methods: PubMed, Embase and Scopus were searched for studies from 1 January 2004 to 31 March 2024. Four cross-sectional studies (n=769) were pooled using a random-effects model. The mean differences (MD) of FMD were reported by comparing exclusive e-cigarette use versus non-use; exclusive e-cigarette use versus combustible cigarette use; and combustible cigarette use versus non-use.

Results: A non-significant reduction in FMD in exclusive e-cigarette use compared to non-use was reported (MD of FMD: -1.47%; 95% CI: -3.96 - 1.02; I²= 84%). Similar MD of FMD in exclusive e-cigarette use and exclusive combustible cigarette use (vs non-use) suggested that both of these products might have comparable adverse influences on endothelial health.

Conclusions: The limited availability of studies assessing the chronic impact of e-cigarette use restricted our ability to provide definitive findings. We emphasize the importance of additional research that explores the long-term impact of e-cigarette use on endothelial dysfunction, and identify key areas and give suggestions for further study.

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通过血流介导的血管扩张测量长期使用电子香烟对内皮功能障碍的影响：系统回顾和荟萃分析。

介绍：尽管电子香烟（电子烟）在市场上被宣传为比可燃香烟更安全的替代品，但长期使用电子烟对血管健康的影响仍不确定。我们的荟萃分析旨在评估长期专门使用电子烟对内皮功能障碍的健康影响，该影响通过血流介导的血管舒张（FMD）进行测量：方法：在PubMed、Embase和Scopus上搜索了2004年1月1日至2024年3月31日期间的研究。采用随机效应模型对四项横断面研究（n=769）进行了汇总。通过比较完全使用电子烟与不使用电子烟、完全使用电子烟与使用可燃卷烟、使用可燃卷烟与不使用可燃卷烟，报告了FMD的平均差异（MD）：与不使用电子烟相比，完全使用电子烟者的 FMD 下降不明显（FMD 的 MD：-1.47%；95% CI：-3.96 - 1.02；I2= 84%）。完全使用电子烟和完全使用可燃卷烟（与不使用相比）的FMD MD相似，这表明这两种产品可能对内皮健康有类似的不利影响：评估使用电子烟的慢性影响的研究有限，这限制了我们提供明确结论的能力。我们强调，必须开展更多研究，探讨使用电子烟对内皮功能障碍的长期影响，并确定关键领域，提出进一步研究的建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tobacco Induced Diseases SUBSTANCE ABUSE-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

CiteScore

5.30

自引率

5.40%

发文量

审稿时长

12 weeks

期刊介绍： Tobacco Induced Diseases encompasses all aspects of research related to the prevention and control of tobacco use at a global level. Preventing diseases attributable to tobacco is only one aspect of the journal, whose overall scope is to provide a forum for the publication of research articles that can contribute to reducing the burden of tobacco induced diseases globally. To address this epidemic we believe that there must be an avenue for the publication of research/policy activities on tobacco control initiatives that may be very important at a regional and national level. This approach provides a very important "hands on" service to the tobacco control community at a global scale - as common problems have common solutions. Hence, we see ourselves as "connectors" within this global community. The journal hence encourages the submission of articles from all medical, biological and psychosocial disciplines, ranging from medical and dental clinicians, through health professionals to basic biomedical and clinical scientists.