Cholecystokinin neurotransmission in the central nervous system: Insights into its role in health and disease.

IF 5 3区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
BioFactors Pub Date : 2024-05-22 DOI:10.1002/biof.2081
Muhammad Asim, Huajie Wang, Abdul Waris, Gao Qianqian, Xi Chen
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引用次数: 0

Abstract

Cholecystokinin (CCK) plays a key role in various brain functions, including both health and disease states. Despite the extensive research conducted on CCK, there remain several important questions regarding its specific role in the brain. As a result, the existing body of literature on the subject is complex and sometimes conflicting. The primary objective of this review article is to provide a comprehensive overview of recent advancements in understanding the central nervous system role of CCK, with a specific emphasis on elucidating CCK's mechanisms for neuroplasticity, exploring its interactions with other neurotransmitters, and discussing its significant involvement in neurological disorders. Studies demonstrate that CCK mediates both inhibitory long-term potentiation (iLTP) and excitatory long-term potentiation (eLTP) in the brain. Activation of the GPR173 receptor could facilitate iLTP, while the Cholecystokinin B receptor (CCKBR) facilitates eLTP. CCK receptors' expression on different neurons regulates activity, neurotransmitter release, and plasticity, emphasizing CCK's role in modulating brain function. Furthermore, CCK plays a pivotal role in modulating emotional states, Alzheimer's disease, addiction, schizophrenia, and epileptic conditions. Targeting CCK cell types and circuits holds promise as a therapeutic strategy for alleviating these brain disorders.

Abstract Image

胆囊收缩素在中枢神经系统中的神经传递:洞察胆囊收缩素在健康和疾病中的作用
胆囊收缩素(CCK)在包括健康和疾病状态在内的各种大脑功能中发挥着关键作用。尽管对 CCK 进行了广泛的研究,但关于它在大脑中的具体作用仍存在几个重要问题。因此,现有的相关文献十分复杂,有时甚至相互矛盾。这篇综述文章的主要目的是全面概述最近在了解 CCK 在中枢神经系统中的作用方面取得的进展,特别强调阐明 CCK 的神经可塑性机制、探讨其与其他神经递质的相互作用并讨论其在神经系统疾病中的重要作用。研究表明,CCK 在大脑中介导抑制性长期电位(iLTP)和兴奋性长期电位(eLTP)。激活 GPR173 受体可促进 iLTP,而胆囊收缩素 B 受体(CCKBR)可促进 eLTP。CCK受体在不同神经元上的表达调控着神经元的活动、神经递质的释放和可塑性,强调了CCK在调节大脑功能中的作用。此外,CCK 在调节情绪状态、阿尔茨海默病、成瘾、精神分裂症和癫痫等疾病中发挥着关键作用。以 CCK 细胞类型和回路为靶点有望成为缓解这些脑部疾病的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BioFactors
BioFactors 生物-内分泌学与代谢
CiteScore
11.50
自引率
3.30%
发文量
96
审稿时长
6-12 weeks
期刊介绍: BioFactors, a journal of the International Union of Biochemistry and Molecular Biology, is devoted to the rapid publication of highly significant original research articles and reviews in experimental biology in health and disease. The word “biofactors” refers to the many compounds that regulate biological functions. Biological factors comprise many molecules produced or modified by living organisms, and present in many essential systems like the blood, the nervous or immunological systems. A non-exhaustive list of biological factors includes neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, receptor ligands and many more. In the group of biofactors we can accommodate several classical molecules not synthetized in the body such as vitamins, micronutrients or essential trace elements. In keeping with this unified view of biochemistry, BioFactors publishes research dealing with the identification of new substances and the elucidation of their functions at the biophysical, biochemical, cellular and human level as well as studies revealing novel functions of already known biofactors. The journal encourages the submission of studies that use biochemistry, biophysics, cell and molecular biology and/or cell signaling approaches.
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