In vitro fertilization and pregnancy outcomes of women with X chromosome abnormality: A case series

IF 1.6 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Birth Defects Research Pub Date : 2024-05-23 DOI:10.1002/bdr2.2349

Ruohan Wang, Linyu Zhang, Jia Liao, Fang Ma, Qianhong Ma

{"title":"In vitro fertilization and pregnancy outcomes of women with X chromosome abnormality: A case series","authors":"Ruohan Wang, Linyu Zhang, Jia Liao, Fang Ma, Qianhong Ma","doi":"10.1002/bdr2.2349","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>To describe and conclude the in vitro fertilization (IVF) results of patients with X chromosome abnormality.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A retrospective case series was conducted. According to the number of normal X, patients were allocated into two groups: Group A (patients with only a normal X, while other X has any types of abnormalities) and Group B (patients have two or more normal X chromosomes). Clinical data, including basic information, fertility information, and IVF outcomes, were collected.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Fourteen patients with X chromosome abnormality were included, among which 13 patients underwent a total of 29 cycles. Patients in Group B had five successful pregnancies and three live births, while no patient in Group A had a clinical pregnancy. Furthermore, the blastocyst formation rate and incidence of pregnancy were significantly lower in Group A (<i>Z</i> = −3.135, <i>p</i> = .002; <i>Z</i> = −2.946, <i>p</i> = .003, respectively). When controlled covariates, the karyotype of one normal X was also a risk factor for both blastocyst formation rate and success pregnancy (<i>β</i> = .820, 95% confidence interval [CI] = 0.458–1.116, <i>β</i> = .333, 95% CI = 0.017–0.494, respectively).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Our results revealed that women with only one normal X might suffer from worse IVF outcomes, mainly blastocyst formation rate, compared with those who had two or more normal X, including mosaic Turner syndrome and 47,XXX.</p>\n </section>\n </div>","PeriodicalId":9121,"journal":{"name":"Birth Defects Research","volume":"116 5","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Birth Defects Research","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bdr2.2349","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

To describe and conclude the in vitro fertilization (IVF) results of patients with X chromosome abnormality.

Methods

A retrospective case series was conducted. According to the number of normal X, patients were allocated into two groups: Group A (patients with only a normal X, while other X has any types of abnormalities) and Group B (patients have two or more normal X chromosomes). Clinical data, including basic information, fertility information, and IVF outcomes, were collected.

Results

Fourteen patients with X chromosome abnormality were included, among which 13 patients underwent a total of 29 cycles. Patients in Group B had five successful pregnancies and three live births, while no patient in Group A had a clinical pregnancy. Furthermore, the blastocyst formation rate and incidence of pregnancy were significantly lower in Group A (Z = −3.135, p = .002; Z = −2.946, p = .003, respectively). When controlled covariates, the karyotype of one normal X was also a risk factor for both blastocyst formation rate and success pregnancy (β = .820, 95% confidence interval [CI] = 0.458–1.116, β = .333, 95% CI = 0.017–0.494, respectively).

Conclusions

Our results revealed that women with only one normal X might suffer from worse IVF outcomes, mainly blastocyst formation rate, compared with those who had two or more normal X, including mosaic Turner syndrome and 47,XXX.

查看原文本刊更多论文

X 染色体异常妇女的体外受精和妊娠结局：病例系列。

背景：描述并总结X染色体异常患者的体外受精（IVF）结果：描述并总结 X 染色体异常患者的体外受精（IVF）结果：方法：进行了一项回顾性病例系列研究。根据正常 X 的数量，将患者分为两组：A组（只有一条X染色体正常，其他X染色体有任何类型异常的患者）和B组（有两条或两条以上X染色体正常的患者）。收集临床数据，包括基本信息、生育信息和试管婴儿结果：结果：共纳入了 14 名 X 染色体异常患者，其中 13 名患者共接受了 29 个周期的治疗。B 组患者成功妊娠 5 例，活产 3 例，而 A 组患者没有临床妊娠。此外，A 组的囊胚形成率和妊娠发生率明显较低（Z = -3.135，p = .002；Z = -2.946，p = .003）。当控制协变量时，一个正常 X 的核型也是囊胚形成率和成功妊娠率的风险因素（β = .820，95% 置信区间 [CI] = 0.458-1.116；β = .333，95% CI = 0.017-0.494）：我们的研究结果表明，与有两个或两个以上正常 X（包括特纳综合征镶嵌型和 47,XXX 型）的妇女相比，只有一个正常 X 的妇女的试管婴儿结果（主要是囊胚形成率）可能更差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.