Exercise protects the hypothalamus morphology from the deleterious effects of high sucrose diet consumption

IF 2.9 4区生物学 Q3 CELL BIOLOGY

Journal of Molecular Histology Pub Date : 2024-05-23 DOI:10.1007/s10735-024-10206-4

Ahmed S. Ahmed, Liju S. Mathew, Marwa M. Mona, Omaima K. Docmac, Hoda A. Ibrahim, Amira M. Elshamy, Ehab M. Hantash, Rasha A. Elsisy

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Abstract

A growing body of evidence suggests that elevated sucrose intake may contribute to the development of neurological disorders. Recognizing that regular exercise has the potential to reduce the occurrence of neuromuscular disorders, the present research investigated the impact of exercise on the redox status of the hypothalamus in mitigating the adverse effects associated with high sucrose intake. Forty Wistar albino rats were subjected to a high sucrose diet, with some groups engaging in exercise for a duration of 3 months. The exercise regimen was found to sustain the redox balance in the hypothalamus. In summary, the consumption of a high sucrose diet resulted in the disturbance of the histological morphology of the hypothalamus, accompanied by an increased percentage of caspase-3 positive cells. Additionally, the high sucrose diet disrupted the oxidant/antioxidant ratio in favor of oxidants, leading to elevated levels of AOPPs and AGEP. Conversely, exercise was effective in restoring most of these values to levels approximating the control group, indicating a potential protective effect of regular exercise against the detrimental impacts of high sucrose dietary consumption on the hypothalamus.

Graphical abstract

Abstract Image

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运动可保护下丘脑形态免受高蔗糖饮食的有害影响。

越来越多的证据表明，蔗糖摄入量过高可能会导致神经系统疾病的发生。由于认识到定期运动有可能减少神经肌肉疾病的发生，本研究调查了运动对下丘脑氧化还原状态的影响，以减轻与高蔗糖摄入相关的不良影响。研究人员对 40 只 Wistar 白化大鼠进行了为期 3 个月的高蔗糖饮食，其中一些组别还进行了运动。结果发现，运动疗法能维持下丘脑的氧化还原平衡。总之，摄入高蔗糖饮食会导致下丘脑组织学形态紊乱，并伴随着 Caspase-3 阳性细胞比例的增加。此外，高蔗糖饮食还破坏了氧化剂/抗氧化剂的比例，使氧化剂占优势，导致AOPPs和AGEP水平升高。与此相反，运动能有效地将这些数值恢复到与对照组接近的水平，这表明经常运动具有潜在的保护作用，能抵御高蔗糖饮食对下丘脑的不利影响。图表摘要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Molecular Histology 生物-细胞生物学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Molecular Histology publishes results of original research on the localization and expression of molecules in animal cells, tissues and organs. Coverage includes studies describing novel cellular or ultrastructural distributions of molecules which provide insight into biochemical or physiological function, development, histologic structure and disease processes. Major research themes of particular interest include: - Cell-Cell and Cell-Matrix Interactions; - Connective Tissues; - Development and Disease; - Neuroscience. Please note that the Journal of Molecular Histology does not consider manuscripts dealing with the application of immunological or other probes on non-standard laboratory animal models unless the results are clearly of significant and general biological importance. The Journal of Molecular Histology publishes full-length original research papers, review articles, short communications and letters to the editors. All manuscripts are typically reviewed by two independent referees. The Journal of Molecular Histology is a continuation of The Histochemical Journal.